J Immunol. 2025 Sep 9:vkaf229. doi: 10.1093/jimmun/vkaf229. Online ahead of print. ABSTRACT Hepatitis B virus (HBV) exclusively infects hepatocytes and produces large quantities of subviral particles containing its surface antigen (HBsAg). T cells play a central role in controlling HBV infection but can also mediate liver injury and contribute to disease progression. However, the mechanisms … Read more

J Immunol. 2025 Sep 4:vkaf215. doi: 10.1093/jimmun/vkaf215. Online ahead of print. ABSTRACT Mounting evidence supports a critical role for central nervous system (CNS) glial cells in neuroinflammation and neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s Disease (PD), Multiple Sclerosis (MS), as well as neurovascular ischemic stroke. Previously, we found that loss of the PD-associated gene … Read more

J Immunol. 2025 Sep 4:vkaf219. doi: 10.1093/jimmun/vkaf219. Online ahead of print. ABSTRACT Tissue resident memory T cells (TRM) provide protection against local re-infection, and yet the interstitial signals that govern their formation and persistence remain poorly defined. Here, we show that antigen-dependent induction of the chemokine receptor CXCR6, is a conserved adaptation to peripheral tissue … Read more

J Immunol. 2025 Sep 3:vkaf226. doi: 10.1093/jimmun/vkaf226. Online ahead of print. ABSTRACT Mucosal-associated invariant T (MAIT) cells play a vital role in immune responses, yet their involvement in autoimmune diseases such as Sjögren’s disease (SjD) remains unclear. CD55, a key regulator of complement activation, influences immune cell function. This study investigates CD55 expression on MAIT … Read more

J Immunol. 2025 Sep 3:vkaf216. doi: 10.1093/jimmun/vkaf216. Online ahead of print. ABSTRACT Transforming growth factor beta (TGFβ) is an immunosuppressive cytokine that is overexpressed in tumor microenvironments. We have shown that CD8+ T cells with genetic ablation of the TGFβ type I receptor, Alk5 (CD8ΔALK5), were more sensitive to αCD3 stimulation resulting in enhanced proliferation … Read more

J Immunol. 2025 Sep 3:vkaf220. doi: 10.1093/jimmun/vkaf220. Online ahead of print. ABSTRACT The Feline McDonough sarcoma-like tyrosine kinase 3 (FLT3)/FLT3 ligand (FLT3L) pathway is associated with pathogenesis of several autoimmune diseases, including Sjögren’s. Inflammatory signals increase FLT3L levels; FLT3L signaling promotes further inflammation through the differentiation, function, and survival of immune cells, including dendritic cells … Read more

J Immunol. 2025 Sep 2:vkaf206. doi: 10.1093/jimmun/vkaf206. Online ahead of print. ABSTRACT Adjuvants are widely used to boost the immune response during vaccination protocols. Our group has previously reported that repeated intraperitoneal administration of alum in mice, known as adjuvant conditioning (AC), creates an immunosuppressive environment that delays allogeneic graft rejection through NLRP3-dependent MDSC expansion. … Read more

J Immunol. 2025 Sep 1:vkaf230. doi: 10.1093/jimmun/vkaf230. Online ahead of print. ABSTRACT The γδ TCR instructively directs both lineage specification and effector programming of developing γδ T cells. However, the way in which different TCR signal strengths and other auxiliary signals coordinate downstream of the γδ TCR to regulate γδ T-cell development remains unclear. In … Read more

J Immunol. 2025 Aug 29:vkaf210. doi: 10.1093/jimmun/vkaf210. Online ahead of print. ABSTRACT Persistent antigen exposure during chronic viral infection and tumor development drives CD8 T cells into an exhausted, hypofunctional state. Understanding the molecular pathways that enforce T-cell exhaustion is critical for improving current immunotherapies. Previously, we have shown the bioactive lipid lysophosphatidic acid (LPA) … Read more

J Immunol. 2025 Aug 1;214(8):1861-1862. doi: 10.1093/jimmun/vkaf175. NO ABSTRACT PMID:40878575 | DOI:10.1093/jimmun/vkaf175