The Journal of Immunology

J Immunol. 2026 Jun 7;215(6):vkag170. doi: 10.1093/jimmun/vkag170. ABSTRACT Memory T-cell inflation is a distinctive immunological phenomenon observed during persistent viral infections such as cytomegalovirus (CMV). Unlike conventional memory T-cell responses, which contract after infection resolution, a subset of CMV-specific T cells undergoes a progressive and sustained expansion, termed “inflation”, which is thought to be critical … Read more

J Immunol. 2026 Jun 7;215(6):vkag135. doi: 10.1093/jimmun/vkag135. ABSTRACT Regulators of G protein signaling (RGS) deactivate G proteins associated with G protein-coupled receptors (GPCRs), a large receptor family with diverse functions. Of the 20 RGS, the Rgs14 single-nucleotide polymorphism is associated with inflammatory bowel disease, and Rgs14 expression is higher in macrophages than in epithelial cells. … Read more

J Immunol. 2026 Jun 7;215(6):vkag143. doi: 10.1093/jimmun/vkag143. ABSTRACT Acquired immunity in mammals depends upon capture and presentation of antigens by specialized macrophage populations in splenic marginal zone and lymph node sinuses and follicular dendritic cells within germinal centers. Cells referred to as follicular dendritic cells in chickens express CSF1R, the receptor for CSF1 and IL34. … Read more

J Immunol. 2026 Jun 7;215(6):vkag133. doi: 10.1093/jimmun/vkag133. ABSTRACT Reproducible and efficient genetic engineering of human NK cells remains a primary challenge to next-generation chimeric antigen receptor (CAR) therapies, specifically for larger constructs with multiple plasmids and transgenes. Lentiviral vectors (LVs) pseudotyped with baboon envelope (BaEV) outperform vesicular stomatitis virus G protein in transducing hematopoietic stem … Read more

J Immunol. 2026 Jun 7;215(6):vkag137. doi: 10.1093/jimmun/vkag137. ABSTRACT In the canonical model of VDJ recombination, a single diversity (D) gene is incorporated into the complementarity-determining region 3 (CDR3) to produce a T cell receptor δ (TCRδ; TRD) or TCRβ (TRB) chain. But by constructing a dataset of more than 2.7 million TRD CDR3 sequences from … Read more

J Immunol. 2026 Jun 7;215(6):vkag125. doi: 10.1093/jimmun/vkag125. ABSTRACT Severe trauma triggers a dynamic disturbance of immune function that can progress from early hyperinflammation to prolonged dysregulation, increasing patient vulnerability to infection and chronic critical illness (CCI). To identify immune features linked to different postinjury clinical trajectories, we prospectively evaluated severely injured trauma patients and categorized … Read more

J Immunol. 2026 Jun 7;215(6):vkag139. doi: 10.1093/jimmun/vkag139. ABSTRACT Protective immunity is induced by both, wild-type measles virus (WT MeV) and live-attenuated (LA) measles virus vaccine (LAMV), affording the opportunity to compare common and selective immunological underpinnings of immune protection. Here, peripheral blood mononuclear cells (PBMCs) were collected from rhesus macaques at several timepoints after infection … Read more

J Immunol. 2026 Jun 7;215(6):vkag159. doi: 10.1093/jimmun/vkag159. ABSTRACT The major capsid protein (MCP), owing to its strong immunogenicity, has emerged as a critical target for largemouth bass ranavirus (LMBV) vaccine development. However, its key antigenic epitopes remain uncharacterized. This study integrated phage display technology with bioinformatics approaches to design a multiepitope vaccine against LMBV. By … Read more

J Immunol. 2026 Jun 7;215(6):vkag149. doi: 10.1093/jimmun/vkag149. ABSTRACT Pathogen-derived RNAs function as pathogen-associated molecular patterns (PAMPs) that activate innate immune responses through pattern recognition receptors (PRRs). While viral RNA is well established as a trigger of antiviral immunity, the identity of bacterial RNA species that function as immunostimulatory ligands and the host PRRs that recognize … Read more

J Immunol. 2026 Jun 7;215(6):vkag114. doi: 10.1093/jimmun/vkag114. ABSTRACT Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is associated with clinical diversity and outcomes ranging from latent TB to active TB with distinct pathophysiologies. However, our understanding of the innate immune mechanisms related to the protection or progression of TB is limited. Among innate immune cells, the … Read more