J Immunol. 2025 Aug 8:vkaf186. doi: 10.1093/jimmun/vkaf186. Online ahead of print. ABSTRACT Tuberculous meningitis (TBM) is the most severe form of tuberculosis, with a fatality rate of 20% to 50% in treated individuals. Although corticosteroid therapy can increase survival in HIV-negative people with TBM, better antimicrobial and host-directed therapies are required to improve outcome. There … Read more

J Immunol. 2025 Aug 8:vkaf191. doi: 10.1093/jimmun/vkaf191. Online ahead of print. ABSTRACT Legionella pneumophila causes severe pneumonia, resulting in acute lung injury. L. pneumophila pneumonia induces neutrophil recruitment to the lung through CXC chemokines. Previously, blocking CXCR2, the common receptor for CXC chemokines, but not CXCL1 or CXCL2, resulted in attenuated neutrophil accumulation and reduced … Read more

J Immunol. 2025 Aug 7:vkaf155. doi: 10.1093/jimmun/vkaf155. Online ahead of print. ABSTRACT Tumor clearance by T cells is impaired by insufficient tumor antigen recognition, insufficient tumor infiltration, and the immunosuppressive tumor microenvironment. Although targeted T cell therapy circumvents failures in tumor antigen recognition, suppression by the tumor microenvironment and failure to infiltrate the tumor can … Read more

J Immunol. 2025 Aug 7:vkaf156. doi: 10.1093/jimmun/vkaf156. Online ahead of print. ABSTRACT Diet-induced obesity leads to dysregulated myelopoiesis and nonresolving inflammation. Such dysregulation could involve epigenetic reprogramming, which can induce long-term changes in hematopoietic stem and progenitor cells (HSPCs). However, whether and how obesity-dysregulated HSPCs impact myelopoiesis in response to tissue injury are not fully … Read more

J Immunol. 2025 Aug 7:vkaf190. doi: 10.1093/jimmun/vkaf190. Online ahead of print. ABSTRACT Immunoglobulin GM (γ marker) allotypes are encoded by 3 very closely linked and highly homologous immunoglobulin heavy chain G (IGHG) genes-IGHG1, IGHG2, and IGHG3-on chromosome 14q32. They are localized on the constant region of γ1, γ2, and γ3 chains. There are currently 18 … Read more

J Immunol. 2025 Aug 7:vkaf160. doi: 10.1093/jimmun/vkaf160. Online ahead of print. ABSTRACT The germinal center (GC) reaction is essential for generating high-quality humoral memory. Positively selected GC B cells must decide whether to remain in the GC for further affinity maturation or differentiate into memory or plasma cells (PCs). Previously, we identified IL-21R and CD40 … Read more

J Immunol. 2025 Aug 7:vkaf141. doi: 10.1093/jimmun/vkaf141. Online ahead of print. ABSTRACT Immunity against skin-invasive pathogens requires mechanisms that rapidly detect, repel, or immobilize the infectious agent. While bacteria often cause painful cutaneous reactions, host skin invasion by the human parasitic helminth Schistosoma mansoni often goes unnoticed. This study interrogated whether pain-sensing skin afferents marked … Read more

J Immunol. 2025 Aug 7:vkaf184. doi: 10.1093/jimmun/vkaf184. Online ahead of print. ABSTRACT Human macrophages differ from their mouse counterparts in multiple metabolic pathways, surface protein expression, and transcription factor biology. Monocyte-derived macrophages (MDMs) from blood are generally used to study human macrophage biology in vitro. However, the use of MDMs as a human macrophage model … Read more

J Immunol. 2025 Aug 1:vkaf094. doi: 10.1093/jimmun/vkaf094. Online ahead of print. ABSTRACT T cells play a pivotal role in the immune system, relying on their somatically rearranged T cell receptor (TCR) to recognize peptide-MHC complexes. A comprehensive and extensively used set of monoclonal antibodies (mAbs) against TCR variable regions was generated in the previous century. … Read more

J Immunol. 2025 Aug 1:vkaf112. doi: 10.1093/jimmun/vkaf112. Online ahead of print. ABSTRACT Total joint arthroplasty is the optimal method for end-stage osteoarticular diseases, but aseptic loosening reduces long-term success. Our prior research demonstrated that wear particles released from loosened prostheses activate macrophages to secrete proinflammatory cytokines, thereby promoting osteoclast formation and osteolysis. Gasdermin D (GSDMD), … Read more