J Immunol. 2025 Jul 14:vkaf148. doi: 10.1093/jimmun/vkaf148. Online ahead of print. ABSTRACT Effective small molecule therapies are a major unmet need in triple-negative breast cancer. Therefore, we examined the mechanism of action of a novel cancer therapeutic target in preclinical mouse models focusing on the α7 nicotinic acetylcholine receptor (CHRNA7). E0771 breast tumor cells were … Read more

J Immunol. 2025 Jul 11:vkaf149. doi: 10.1093/jimmun/vkaf149. Online ahead of print. ABSTRACT Plasma cells (PC) produce antigen-specific antibodies following vaccination or infection, playing a vital role in protective immunity. Not all PC have equal lifespans, yet how lifespans are determined remains unknown. Here, we describe a system for the generation of persistent PC in mice … Read more

J Immunol. 2025 Jul 10:vkaf173. doi: 10.1093/jimmun/vkaf173. Online ahead of print. NO ABSTRACT PMID:40638862 | DOI:10.1093/jimmun/vkaf173

J Immunol. 2025 Jul 10:vkaf138. doi: 10.1093/jimmun/vkaf138. Online ahead of print. ABSTRACT Th2 cells must sense and adapt to the tissue milieu to provide protective host immunity and tissue repair. Here, we examined the mechanisms promoting Th2 cell differentiation and function within the small intestinal lamina propria. Single cell RNA-seq analyses of CD4+ T cells … Read more

J Immunol. 2025 Jul 9:vkaf131. doi: 10.1093/jimmun/vkaf131. Online ahead of print. ABSTRACT The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway, a sensor of cytosolic DNA, orchestrates the production of proinflammatory cytokines, chemokines, and type I interferons (IFN-Is), thereby contributing to spontaneous tumor surveillance. Intratumoral delivery of synthetic STING agonists induces IFN-I-dependent tumor regression in … Read more

J Immunol. 2025 Jul 7:vkaf097. doi: 10.1093/jimmun/vkaf097. Online ahead of print. ABSTRACT Acute lung injury (ALI) post-lung transplantation (LT) is a major clinical challenge. This study investigates the role of exosomal miR-124-3p in modulating macrophage polarization and ameliorating ALI. Using male C57BL/6J mice, we established a left lung orthotopic transplantation model. Transcriptomic analysis revealed that … Read more

J Immunol. 2025 Jul 3:vkaf136. doi: 10.1093/jimmun/vkaf136. Online ahead of print. ABSTRACT Tissue stromal cells are composed of numerous cell types with phenotypical and functional heterogeneity. Apart from providing structural support, they are emerging as key orchestrators of both activation and repression of immune responses in tissue microenvironment. The underlying mechanisms by which stromal cells … Read more

J Immunol. 2025 Jul 3:vkaf147. doi: 10.1093/jimmun/vkaf147. Online ahead of print. ABSTRACT Type 2 memory B cells (mBC2), identified in mice as IgG1+CD23+IL-4Rα+CD38+ B cells, which require IL-4 for genesis, are precursors for IgE plasma cells (PC) and considered key in allergy. While IL-21 is critical for normal mBC differentiation, its involvement in mBC2 formation … Read more

J Immunol. 2025 Jul 3:vkaf133. doi: 10.1093/jimmun/vkaf133. Online ahead of print. ABSTRACT Borrelia burgdorferi (or Borreliella burgdorferi), the extracellular spirochete responsible for Lyme disease, elicits a type I interferon (IFN-I) response critical for the development of Lyme arthritis. However, the specific pathogen-associated molecular pattern (PAMP) driving this response remains unidentified. Previous studies have reported that … Read more

J Immunol. 2025 Jul 1:vkaf135. doi: 10.1093/jimmun/vkaf135. Online ahead of print. ABSTRACT Macrophages, the central mediators of innate immune responses, can adapt and build nonspecific memory, also known as innate immune memory or trained immunity. Training of macrophages occurs through epigenetic changes and metabolic rewiring, which fuels macrophage responsiveness. In addition to training in response … Read more