The Journal of Immunology

J Immunol. 2026 Mar 25;215(S3):vkaf337. doi: 10.1093/jimmun/vkaf337. ABSTRACT Body-brain neuroimmune signaling is important for maintaining homeostasis and behavior. Dysregulation of these interoceptive communication pathways leads to compromised physical and mental health often associated with psychiatric disorders. Specialized interoceptive nodes considered as “gateways” to the brain offer an interface for communication with the periphery to aid … Read more

J Immunol. 2026 Mar 25;215(S3):vkaf308. doi: 10.1093/jimmun/vkaf308. ABSTRACT Subdural central nervous system (CNS)-associated macrophages (CAMs), encompassing macrophages of the leptomeninges and perivascular spaces, serve as the primary immune sentinels at the CNS interfaces. These cells have been suggested to be indispensable for maintaining homeostasis and orchestrating responses in pathological states. Under physiological conditions, CAMs continuously … Read more

J Immunol. 2026 Mar 25;215(S3):vkag003. doi: 10.1093/jimmun/vkag003. ABSTRACT Fibroblasts in the central nervous system (CNS) are restricted to the organ’s borders, providing mechanical protection, barrier functions, and an infrastructure for the pervading vasculature. An immunological function for these cells has not been considered until recently. In the last decade, new insights into CNS immune surveillance, … Read more

J Immunol. 2026 Mar 25;215(S3):vkaf326. doi: 10.1093/jimmun/vkaf326. ABSTRACT Olfaction, or the sense of smell, is the ability to detect airborne chemicals that transmit environmental information. Evolutionarily, this sense is essential for finding and judging the safety of food, mediating social relationships, marking territory, and assessing danger. In humans, olfaction is commonly thought to have a … Read more

J Immunol. 2026 Mar 25;215(S3):vkaf322. doi: 10.1093/jimmun/vkaf322. ABSTRACT The choroid plexus (ChP) is increasingly recognized as a dynamic neuroimmune interface that integrates peripheral and central signals to regulate cerebrospinal fluid (CSF) homeostasis, leukocyte trafficking, and inflammatory tone within the central nervous system (CNS). Recent studies reveal that beyond their classic roles in CSF production and … Read more

J Immunol. 2026 Mar 25;215(S3):vkaf338. doi: 10.1093/jimmun/vkaf338. NO ABSTRACT PMID:41876362 | DOI:10.1093/jimmun/vkaf338

J Immunol. 2026 Mar 17;215(3):vkag033. doi: 10.1093/jimmun/vkag033. ABSTRACT Interleukin 1-beta (IL-1β) is an inflammatory cytokine produced by myeloid cells in response to infection or sterile tissue damage. Secretion of bioactive IL-1β from macrophages (Mφ) or dendritic cells (DC) downstream of activated NLRP3/caspase-1 inflammasomes is the best characterized model; this is mediated by caspase-1 cleavage of … Read more

J Immunol. 2026 Mar 17;215(3):vkag009. doi: 10.1093/jimmun/vkag009. ABSTRACT Echoviruses commonly infect humans and can cause severe outcomes, including meningitis and liver failure, especially in neonates and immunocompromised individuals. Although recent progress has been made in understanding acute pathogenesis and innate immunity to echoviruses, adaptive immune responses remain poorly defined, in part due to the lack … Read more

J Immunol. 2026 Mar 17;215(3):vkag001. doi: 10.1093/jimmun/vkag001. ABSTRACT The traditional view of the immune system distinguishes between the innate immune system, which serves as the host’s first line of defense against pathogens, and the adaptive immune system, which evolved to manage more complex or recurrent infections. However, the discovery of evolutionarily conserved mechanisms in innate … Read more

J Immunol. 2026 Mar 19:vkag022. doi: 10.1093/jimmun/vkag022. Online ahead of print. ABSTRACT The Syrian hamster (Mesocricetus auratus) is an important model for human infectious diseases, particularly those that infect the respiratory tract, due to having similar disease progression and immune responses as humans. However, immune repertoire studies are extremely limited due to incomplete genomic characterization … Read more