J Immunol. 2025 May 27:vkaf050. doi: 10.1093/jimmun/vkaf050. Online ahead of print. ABSTRACT Bovine leukemia virus (BLV) causes enzootic bovine leukosis (EBL), a B-cell lymphoma in cattle. Previous studies have demonstrated that T cells of BLV-infected cattle show increased expression of immune checkpoint molecules, including programmed death-1 (PD-1), lymphocyte-activation gene-3 (LAG-3), cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4), and … Read more

J Immunol. 2025 Feb 27:vkaf104. doi: 10.1093/jimmun/vkaf104. Online ahead of print. ABSTRACT Strain 68-1 rhesus CMV (RhCMV) vectors induce immune responses that mediate early, complete replication arrest of SIV infection in ∼60% of vaccinated rhesus macaques (RMs). This unique efficacy depends on the ability of these vectors to elicit effector memory (EM)-biased CD8+ T cells … Read more

J Immunol. 2025 May 25:vkaf106. doi: 10.1093/jimmun/vkaf106. Online ahead of print. NO ABSTRACT PMID:40414619 | DOI:10.1093/jimmun/vkaf106

J Immunol. 2025 May 25:vkaf073. doi: 10.1093/jimmun/vkaf073. Online ahead of print. ABSTRACT The mechanisms through which heterogeneous nuclear ribonucleoprotein A2B1 (HNRNPA2B1) contributes to innate immune gene regulation are poorly understood. To fill this gap, we generated a myeloid lineage-specific HNRNPA2B1-conditional mouse using LysMCre. In an endotoxic shock model, HNRNPA2B1-deficient mice exhibit dampened expression of inflammatory … Read more

J Immunol. 2025 May 23:vkaf102. doi: 10.1093/jimmun/vkaf102. Online ahead of print. ABSTRACT This study investigates the diagnostic potential of matrix metalloproteinase-9 (MMP-9), IL-8, and myeloperoxidase (MPO) in bronchoalveolar lavage fluid (BALF) as combined biomarkers for post-infectious bronchiolitis obliterans (PIBO) in children. BALF samples from children with PIBO were analyzed using ELISA to quantify MMP-9, IL-8, … Read more

J Immunol. 2025 May 22:vkaf101. doi: 10.1093/jimmun/vkaf101. Online ahead of print. ABSTRACT Higher circulating SARS-CoV-2 IgG titers correlate with SARS-CoV-2 ex vivo viral neutralization, but how well this translates to clinical protection in the real-world setting is unclear. In a prospective cohort study, we enrolled 44 SARS-CoV-2 negative, confirmed SARS-CoV-2 close contacts. Receptor-binding domain (RBD) … Read more

J Immunol. 2025 May 22:vkaf086. doi: 10.1093/jimmun/vkaf086. Online ahead of print. ABSTRACT Memory T helper (Th) cells, generated in response to immunogenic challenges, are crucial in orchestrating adaptive immune responses. Acetylcholine (ACh), a key neurotransmitter of the parasympathetic nervous system, modulates immune function via muscarinic ACh receptors (mAChRs). This study investigates the role of mAChRs, … Read more

J Immunol. 2025 May 23:vkaf080. doi: 10.1093/jimmun/vkaf080. Online ahead of print. ABSTRACT Cancer immunotherapeutic CpG oligodeoxynucleotide (ODN) is an agonist for TLR9 and a potent inducer of inflammatory cytokines and type I interferon. Clinical trials of CpG ODNs highlight the urgent need for effective TLR9 agonist CpG ODNs in humans. Here, we developed a highly … Read more

J Immunol. 2025 May 21:vkaf092. doi: 10.1093/jimmun/vkaf092. Online ahead of print. ABSTRACT Influenza A(H3N2) viruses are currently evolving faster than any other subtype of seasonal influenza. As a result, vaccine efficacy can vary widely from one year to the next, and the wild-type antigens in the seasonal vaccine need to be updated frequently to stay … Read more

J Immunol. 2025 May 20:vkaf108. doi: 10.1093/jimmun/vkaf108. Online ahead of print. NO ABSTRACT PMID:40393776 | DOI:10.1093/jimmun/vkaf108