The Journal of Immunology

J Immunol. 2024 Nov 1;213(9):1267-1277. doi: 10.4049/jimmunol.2400020. ABSTRACT The human skin forms a dynamic barrier to physical injuries and microbial invasion. Constant interactions between stroma and tissue-confined immune cells maintain skin homeostasis. However, the cellular interactions that maintain skin health also contribute to focal immunopathology. Psoriasis is a common disease that manifests with focal pathology … Read more

J Immunol. 2024 Nov 1;213(9):1265. doi: 10.4049/jimmunol.2490015. NO ABSTRACT PMID:39432868 | DOI:10.4049/jimmunol.2490015

J Immunol. 2024 Oct 18:ji2300742. doi: 10.4049/jimmunol.2300742. Online ahead of print. ABSTRACT CMV infection and Th17 cells are independently associated with increased risk for late allograft loss after renal transplantation. Although CMV-specific Th17 cells are detectable in animal models and nontransplant clinical populations, evidence linking CMV and Th17 cells after renal transplantation remains unclear. This … Read more

J Immunol. 2024 Oct 18:ji2400189. doi: 10.4049/jimmunol.2400189. Online ahead of print. ABSTRACT Autophagy serves as a critical regulator of immune responses in sepsis. Macrophages are vital constituents of both innate and adaptive immunity. In this study, we delved into the intricate role of p120-catenin (p120) in orchestrating autophagy in macrophages in response to endotoxin stimulation. … Read more

J Immunol. 2024 Oct 16:ji2400282. doi: 10.4049/jimmunol.2400282. Online ahead of print. ABSTRACT AMP-activated protein kinase (AMPK) plays a crucial role in governing essential cellular functions such as growth, proliferation, and survival. Previously, we observed increased vulnerability to bacterial (Staphylococcus aureus) endophthalmitis in global AMPKα1 knockout mice. In this study, we investigated the specific involvement of … Read more

J Immunol. 2024 Oct 16:ji2400295. doi: 10.4049/jimmunol.2400295. Online ahead of print. ABSTRACT Resident memory T cells (TRM cells) have been described in barrier tissues as having a “sensing and alarm” function where, upon sensing cognate Ag, they alarm the surrounding tissue and orchestrate local recruitment and activation of immune cells. In the immunologically unique and … Read more

J Immunol. 2024 Oct 14:ji2400088. doi: 10.4049/jimmunol.2400088. Online ahead of print. ABSTRACT Hepatitis B virus (HBV) is the most common chronic viral infection globally, affecting ∼360 million people and causing about 1 million deaths annually due to end-stage liver disease or hepatocellular carcinoma. Current antiviral treatments rarely achieve a functional cure for chronic hepatitis B, … Read more

J Immunol. 2024 Oct 14:ji2400445. doi: 10.4049/jimmunol.2400445. Online ahead of print. ABSTRACT The immunomodulatory enzyme IDO2 is an essential mediator of autoantibody production and joint inflammation in preclinical models of autoimmune arthritis. Although originally identified as a tryptophan-catabolizing enzyme, we recently discovered a previously unknown nonenzymatic pathway is essential for the proarthritic function of IDO2. … Read more

J Immunol. 2024 Oct 11:ji2400215. doi: 10.4049/jimmunol.2400215. Online ahead of print. ABSTRACT Monocytes and macrophages are central to host defense but also contribute to inflammation-associated pathology. Efforts to manipulate monocyte and macrophage function are limited by our ability to effectively quantify the functional programs of these cells. We identified the gene Fth1, which encodes the … Read more

J Immunol. 2024 Oct 11:ji2400395. doi: 10.4049/jimmunol.2400395. Online ahead of print. ABSTRACT Multisystem inflammatory syndrome in children (MIS-C) is a severe complication of SARS-CoV-2 infection characterized by multiorgan involvement and inflammation. Testing of cellular function ex vivo to understand the aberrant immune response in MIS-C is limited. Despite strong Ab production in MIS-C, SARS-CoV-2 nucleic … Read more