J Immunol. 2025 May 7:vkaf082. doi: 10.1093/jimmun/vkaf082. Online ahead of print. ABSTRACT A novel subset of classical major histocompatibility complex class I molecules has recently been identified in rhesus monkeys that mediates the presentation of N-myristoylated lipopeptides, rather than conventional peptides, to CD8+ cytotoxic T lymphocytes (CTLs). For example, the rhesus Mamu-B*098 allomorph binds an … Read more

J Immunol. 2025 May 5:vkaf075. doi: 10.1093/jimmun/vkaf075. Online ahead of print. ABSTRACT T cells undergo many metabolic changes throughout the different phases of their response in lymphoid and nonlymphoid tissues. Cell metabolism meets demands for energy and biosynthesis, particularly during cell division and effector differentiation. As costimulatory receptors, CD28 and various TNF receptor (TNFR) family … Read more

J Immunol. 2025 May 2:vkaf062. doi: 10.1093/jimmun/vkaf062. Online ahead of print. ABSTRACT Expression of the BCR is essential for survival, development, and effector functions of B cells. Naive B cells express surface IgM and IgD, while surface IgG1 is expressed by class-switched (memory) B cells. Despite similar overall structures, the different BCR isotypes show differences … Read more

J Immunol. 2025 Apr 30:vkaf043. doi: 10.1093/jimmun/vkaf043. Online ahead of print. ABSTRACT Immunostimulants can be highly effective anti-cancer therapeutics; however, their systemic use is often limited by adverse reactions (AEs). Formulating immunostimulants into nanoparticle systems can potentially alleviate these, but nanoparticle design is key. In previous studies, we encountered anti-nanoparticle reactions with systemically administered PEGylated … Read more

J Immunol. 2025 Apr 30:vkaf066. doi: 10.1093/jimmun/vkaf066. Online ahead of print. ABSTRACT Porcine respiratory coronavirus (PRCV) is a naturally occurring pneumotropic coronavirus in the pig, providing a valuable large animal model to study acute respiratory disease. PRCV pathogenesis and the resulting immune response were investigated in pigs, the natural large animal host. We compared 2 … Read more

J Immunol. 2025 Apr 28:vkaf070. doi: 10.1093/jimmun/vkaf070. Online ahead of print. NO ABSTRACT PMID:40294373 | DOI:10.1093/jimmun/vkaf070

J Immunol. 2025 Apr 25:vkaf028. doi: 10.1093/jimmun/vkaf028. Online ahead of print. ABSTRACT Mannose-binding lectin (MBL) is a vital and versatile component of innate immunity, which plays an essential role in host defense. In mammals, MBL performs multiple functions, including pattern recognition, complement activation, and phagocytosis. Previous studies revealed that OnMBL can promote the opsonophagocytosis of … Read more

J Immunol. 2025 Apr 25:vkae058. doi: 10.1093/jimmun/vkae058. Online ahead of print. ABSTRACT The capacity of Mycobacterium tuberculosis (Mtb) to establish long-term survival is attributed to its ability to subvert host defense mechanisms, especially macrophages. Although Mtb lipids are believed to play a role in this host-pathogen crosstalk, how mycobacterial lipids drive this complex interaction is … Read more

J Immunol. 2025 Apr 25:vkaf074. doi: 10.1093/jimmun/vkaf074. Online ahead of print. ABSTRACT T cell-independent type 2 antigens (TI-2 Ags), such as pneumococcal polysaccharides, elicit weak immunoglobulin G (IgG) responses and are refractive to boosting. Overcoming this challenge is critical for improving vaccines. Previously, we demonstrated a lipid-based adjuvant composed of monophosphoryl lipid A, synthetic cord … Read more

J Immunol. 2025 Apr 25:vkaf057. doi: 10.1093/jimmun/vkaf057. Online ahead of print. ABSTRACT Human metapneumovirus (HMPV) is a leading cause of lower respiratory tract infection in children accounting for 7% of acute care visits and hospitalizations. In particular, neonates and infants have worse outcomes with HMPV infection. The neonatal immune system is regulated to favor anti-inflammatory … Read more