The Journal of Immunology

J Immunol. 2026 Feb 9;215(2):vkaf351. doi: 10.1093/jimmun/vkaf351. ABSTRACT Sepsis-induced liver injury involves profound immune dysregulation. Natural compounds such as artesunate (ART), capsaicin (CAP), and oridonin (ORI) have demonstrated efficacy in mitigating systemic inflammation; however, their comparative cellular mechanisms in sepsis remain poorly characterized. Here, we integrated and reanalyzed the single-cell transcriptomic datasets of murine livers … Read more

J Immunol. 2026 Jan 21;215(1):vkaf222. doi: 10.1093/jimmun/vkaf222. ABSTRACT During the progression of acetaminophen (N-acetyl-para-aminophenol [APAP])-induced liver injury, the innate immune response is implicated in the induction of tissue damage. However, the precise cellular and molecular mechanisms underlying this process are not yet completely elucidated. CARD9 is known to modulate the activation of the NF-κB family … Read more

J Immunol. 2025 Dec 28:vkaf349. doi: 10.1093/jimmun/vkaf349. Online ahead of print. ABSTRACT Coronin family proteins are involved in various cellular processes, such as actin cytoskeleton reorganization, cell motility, and vesicular trafficking. Coronin-1, encoded by Coro1a, is specifically expressed in immune cells, and its defect causes severe immunodeficiencies. However, the regulatory mechanisms of Coro1a expression in … Read more

J Immunol. 2025 Dec 27:vkaf330. doi: 10.1093/jimmun/vkaf330. Online ahead of print. ABSTRACT Type 1 diabetes (T1D) results from immune-mediated destruction of pancreatic beta cells. B cells serve as critical antigen-presenting cells whose autoreactive specificities drive disease progression. Conversely, IL-10 producing regulatory B cells (Bregs) exert immunosuppressive functions and have been shown to protect against autoimmunity … Read more

J Immunol. 2025 Dec 25:vkaf315. doi: 10.1093/jimmun/vkaf315. Online ahead of print. ABSTRACT Previous studies have reported that African swine fever virus (ASFV) infection can induce inflammatory responses through the activation of the NLRP3 inflammasome, resulting in the release of IL-1β and the cleavage of gasdermin D. However, the mechanism by which pattern recognition receptors in … Read more

J Immunol. 2025 Dec 25:vkaf305. doi: 10.1093/jimmun/vkaf305. Online ahead of print. ABSTRACT The SARS-CoV-2 pandemic underscored the need for innovative approaches to study humoral immunity and isolate monoclonal antibodies (mAbs) with diagnostic and therapeutic potential. Current methods for repertoire analysis at the clonal level require large-scale recombinant mAb production, limiting accessibility and delaying functional insight. … Read more

J Immunol. 2025 Dec 22:vkaf319. doi: 10.1093/jimmun/vkaf319. Online ahead of print. ABSTRACT The innate immune system of teleost fish, such as Takifugu obscurus, depends on pattern recognition receptors to detect microbes and mount immune responses. In this study, a new collectin gene was identified in T. obscurus, designated ToCL-11. The full-length cDNA of ToCL-11 encodes … Read more

J Immunol. 2025 Dec 13:vkaf328. doi: 10.1093/jimmun/vkaf328. Online ahead of print. ABSTRACT B cells play critical roles in humoral immunity to infection, vaccination, and autoimmunity. The differentiation of B cells into antibody-producing plasma cells (PCs) has been extensively studied, but the role of metabolic transporters that mediate nutrient uptake during PC differentiation is not well-understood. … Read more

J Immunol. 2025 Dec 13:vkaf169. doi: 10.1093/jimmun/vkaf169. Online ahead of print. ABSTRACT Chronic graft-versus-host disease (cGVHD) develops with complex interactions between immune cells and cytokines, leading to irreversible fibrosis. Severe cGVHD impairs quality of life and is associated with nonrelapse mortality; however, effective treatments are limited. Recombinant human soluble thrombomodulin (rTM), a novel anticoagulant consisting … Read more

J Immunol. 2025 Dec 12:vkaf317. doi: 10.1093/jimmun/vkaf317. Online ahead of print. ABSTRACT Human macrophages (MΦs) reside in tissues and develop tissue-specific identities. While studies in mice have identified molecular signatures for site-specific MΦ differentiation, less is known about the transcriptional profiles of human MΦs in distinct sites, including mucosal tissues and lymphoid organs during homeostasis … Read more