The Journal of Immunology

J Immunol. 2024 Oct 9:ji2400470. doi: 10.4049/jimmunol.2400470. Online ahead of print. ABSTRACT Medina-Ruiz, L., R. Bartolini, H. Mathie, H. A. Halawa, F. Schuette, M. Cunningham, and G. J. Graham. 2024. CCR1 and CCR2 coexpression on monocytes is nonredundant and delineates a distinct monocyte subpopulation. J. Immunol. 213: 214-225. Fabian Schuette was inadvertently left off the … Read more

J Immunol. 2024 Oct 9:ji2300632. doi: 10.4049/jimmunol.2300632. Online ahead of print. ABSTRACT Plerixafor, a hematopoietic stem cell mobilization agent, increases the peripheral blood content of effector and regulatory T cells and may have beneficial effects on cardiac allograft vasculopathy. The aim of the current study was to evaluate its effects in a murine aortic allograft … Read more

J Immunol. 2024 Jul 15;213(2):107. doi: 10.4049/jimmunol.2490007. NO ABSTRACT PMID:39382447 | DOI:10.4049/jimmunol.2490007

J Immunol. 2024 Oct 15;213(8):1049-1051. doi: 10.4049/jimmunol.2400510. ABSTRACT This Pillars of Immunology article is a commentary on “Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis,” a pivotal article written by H. R. Conti, F. Shen, N. Nayyar, E. Stocum, J. N. Sun, M. J. Lindemann, A. W. Ho, … Read more

J Immunol. 2024 Oct 15;213(8):1047. doi: 10.4049/jimmunol.2490014. NO ABSTRACT PMID:39374467 | DOI:10.4049/jimmunol.2490014

J Immunol. 2024 Oct 7:ji2400344. doi: 10.4049/jimmunol.2400344. Online ahead of print. ABSTRACT Type 1 diabetes (T1D) is a chronic autoimmune disease that is caused by a combination of genetic and environmental risk factors. In this study, we sought to determine whether a known genetic risk factor, the rs1990760 single nucleotide polymorphism (SNP) (A946T) in IFIH1, … Read more

J Immunol. 2024 Oct 7:ji2400213. doi: 10.4049/jimmunol.2400213. Online ahead of print. ABSTRACT CD8+ T cells differentiate into two subpopulations in response to acute viral infection: memory precursor effector cells (MPECs) and short-lived effector cells (SLECs). MPECs and SLECs are epigenetically distinct; however, the epigenetic regulators required for formation of these subpopulations are mostly unknown. In … Read more

J Immunol. 2024 Oct 7:ji2300827. doi: 10.4049/jimmunol.2300827. Online ahead of print. ABSTRACT Identification of early immune signatures associated with acute myeloid leukemia (AML) relapse following hematopoietic stem cell transplant (HSCT) is critical for patient outcomes. We analyzed PBMCs from 58 patients with AML undergoing HSCT, focusing on T cell subsets and functional profiles. High-dimensional flow … Read more

J Immunol. 2024 Oct 4:ji2400127. doi: 10.4049/jimmunol.2400127. Online ahead of print. ABSTRACT Lanthionine synthetase C-like 2 (LANCL2) is an immunoregulatory therapeutic target for autoimmune diseases. NIM-1324 is an investigational new drug aimed at addressing the unmet clinical needs of patients with systemic lupus erythematosus (SLE) by targeting the LANCL2 immunometabolic pathway. In R848 and bm12 … Read more

J Immunol. 2024 Sep 30:ji2400233. doi: 10.4049/jimmunol.2400233. Online ahead of print. ABSTRACT Bacteria-Ig interactions maintain homeostasis in the gut through the clearance of pathogenic bacteria and the development of immune tolerance to inflammatory bacteria; whether similar interactions modulate inflammation and bacterial colonization in the female genital tract is uncertain. In this study, we used a … Read more