J Immunol. 2025 Apr 24:vkaf068. doi: 10.1093/jimmun/vkaf068. Online ahead of print. ABSTRACT We have designed the first antigen-less pro-vaccine, named 8206, for treating autoimmune diseases. Composed of dexamethasone, rapamycin, and R848 at a mass ratio of 8:20:6, 8206 is a complete tolerogenic adjuvant that acts systemically to form an active vaccine in situ with endogenous … Read more

J Immunol. 2025 Apr 23:vkaf063. doi: 10.1093/jimmun/vkaf063. Online ahead of print. ABSTRACT Human epidermal growth factor receptor 2 (HER2) is highly overexpressed on the surface of breast cancer cells, presenting an attractive target for therapeutic antibodies. Antibody-dependent cellular cytotoxicity (ADCC) is a central mechanism underlying the antitumor activities of anti-HER2 monoclonal antibodies. Here, we engineered … Read more

J Immunol. 2025 Apr 23:vkaf067. doi: 10.1093/jimmun/vkaf067. Online ahead of print. ABSTRACT Regulatory T cells (Tregs) can persist as memory cells (mTregs) in both infectious and non-infectious settings. However, their functional behavior, phenotypic stability, and suppressive properties upon antigen re-exposure remain poorly understood. Emerging evidence suggests that mTregs exhibit enhanced proliferation and suppressive capacity upon … Read more

J Immunol. 2025 Apr 23:vkaf054. doi: 10.1093/jimmun/vkaf054. Online ahead of print. ABSTRACT Autoimmune regulator (AIRE), a transcriptional regulator expressed by medullary thymic epithelial cells, is required for shaping the self-antigen tolerant T cell receptor repertoire. In humans, AIRE mutations caues autoimmune polyglandular syndrome type 1. Among other symptoms, men with autoimmune polyglandular syndrome type 1 … Read more

J Immunol. 2025 Apr 22:vkae066. doi: 10.1093/jimmun/vkae066. Online ahead of print. ABSTRACT Gfi1 is a transcriptional repressor that plays a critical role in hematopoiesis. Gfi1 represses its target genes primarily through interacting with the histone demethylase LSD1 via its SNAG domain. A major function of Gfi1 is to inhibit DNA damage-induced apoptosis through its involvement … Read more

J Immunol. 2025 Apr 22:vkaf072. doi: 10.1093/jimmun/vkaf072. Online ahead of print. ABSTRACT This Pillars of Immunology article is a commentary on 2 pivotal articles that shaped the CD40-CD40L field – “Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM,” written by U. Korthäuer, D. Graf, H.W. Mages, F. Brière, M. Padayachee, S. Malcolm, … Read more

J Immunol. 2025 Apr 21:vkaf053. doi: 10.1093/jimmun/vkaf053. Online ahead of print. ABSTRACT The complement system is an essential part of innate immunity, and dysregulated complement is an underlying driver in many inflammatory and autoimmune diseases. Currently approved complement-focused therapeutics rely on systemic blockade of complement activation, but a major challenge with this approach is that … Read more

J Immunol. 2025 Apr 21:vkaf061. doi: 10.1093/jimmun/vkaf061. Online ahead of print. ABSTRACT This review explores interleukin (IL)-17D and its receptor CD93, highlighting their structural, functional, and clinical aspects. Identifying CD93 as the receptor for IL-17D has advanced understanding of the IL-17 family and its signaling pathways. IL-17D, with its unique glycoprotein structure, plays diverse roles … Read more

J Immunol. 2025 Apr 21:vkaf051. doi: 10.1093/jimmun/vkaf051. Online ahead of print. ABSTRACT Type 1 innate lymphoid cells (ILC1s) and conventional natural killer cells belong to the group 1 ILCs (gILC1), characterized largely by T-bet expression and interferon γ secretion. While much has been done to define factors that regulate the development, differentiation, and effector functions … Read more

J Immunol. 2025 Apr 18:vkaf046. doi: 10.1093/jimmun/vkaf046. Online ahead of print. ABSTRACT T helper cell differentiation is one of the key developmental events in the peripheral immune regulations, resulting in better adaptation to the nature of infection and inflammation. While it is known that several factors are involved in this differentiation, including subsets of antigen-presenting … Read more