The Journal of Immunology

J Immunol. 2025 Dec 12:vkaf298. doi: 10.1093/jimmun/vkaf298. Online ahead of print. ABSTRACT Pregnancy is characterized by dynamic immunological adaptations which are essential for maintaining both maternal and fetal health. The first-time use of coronavirus disease 2019 (COVID-19) vaccines in pregnant individuals presented an opportunity to discover pregnancy-specific immunoproteomic signatures across gestation. In this study, we … Read more

J Immunol. 2025 Dec 11:vkaf221. doi: 10.1093/jimmun/vkaf221. Online ahead of print. ABSTRACT Tristetraprolin (TTP) is an anti-inflammatory protein that mediates messenger RNA (mRNA) decay of certain transcripts, especially those encoding proinflammatory cytokines. TTP modulates various pathological outcomes in diverse inflammatory diseases; however, its role in ozone (O3)-induced acute lung injury (ALI) has never been tested. … Read more

J Immunol. 2025 Dec 10:vkaf297. doi: 10.1093/jimmun/vkaf297. Online ahead of print. ABSTRACT Enhancing regulatory T cell (Treg) function offers a compelling therapeutic strategy for autoimmune disease. Engineered IL-2 muteins selectively expand functional Tregs with minimal impact on other immune cells, but their potential to compromise antiviral immunity remains largely unexplored. Here, we used a murine … Read more

J Immunol. 2025 Dec 10:vkaf303. doi: 10.1093/jimmun/vkaf303. Online ahead of print. ABSTRACT Regulatory T cell (Treg)-biased IL-2/anti-IL-2 monoclonal antibody complexes (IL-2c) can preferentially deliver IL-2 to CD25+ Tregs, causing proliferation of Tregs that is potentially advantageous in transplantation. We tested the ability of IL-2c to prolong murine cardiac allograft survival. C57BL/6 (H-2b) mice received fully … Read more

J Immunol. 2025 Dec 8:vkaf325. doi: 10.1093/jimmun/vkaf325. Online ahead of print. ABSTRACT Freshwater crayfish as most aquatic crustaceans live for up to 20-30 years on the bottom of lakes and rivers, constantly exposed to millions of microorganisms. Consequently, they must have an effective immune system to combat and eliminate pathogens. The main immune cells are … Read more

J Immunol. 2025 Dec 6:vkaf302. doi: 10.1093/jimmun/vkaf302. Online ahead of print. ABSTRACT Candidozyma auris (formerly Candida auris) is an emerging multidrug-resistant pathogenic fungus that has rapidly spread across the world. Due to the high frequency of multidrug-resistant strains and mortality rate, C. auris is considered a critical health threat by the Centers for Disease Control … Read more

J Immunol. 2025 Dec 5:vkaf324. doi: 10.1093/jimmun/vkaf324. Online ahead of print. ABSTRACT Neutrophils are the first line of defense against fungal infection and other microbial pathogens. Through alternative pathway of complement activation in innate immunity, complement fragments (opsonin) generated promote phagocytosis of the yeast forms of fungal pathogens such as Candida albicans. However, when complement … Read more

J Immunol. 2025 Dec 3:vkaf310. doi: 10.1093/jimmun/vkaf310. Online ahead of print. ABSTRACT IgA-secreting plasma cells (PCs) provide durable humoral immunity by supplying critical antibodies to mucosal and systemic sites. These cells are found in large numbers in the gut lamina propria and the bone marrow (BM). In this study, we found that IgA+ PCs in … Read more

J Immunol. 2025 Dec 2:vkaf318. doi: 10.1093/jimmun/vkaf318. Online ahead of print. ABSTRACT Helper T cells (CD4 T cells) are lynchpins of adaptive immune responses. Each CD4 T cell expresses a single T-cell receptor, recognizing an epitope presented by major histocompatibility complex class II (MHC-II). Due to the enormous diversity of the T-cell repertoire, it is … Read more

J Immunol. 2025 Nov 29:vkaf290. doi: 10.1093/jimmun/vkaf290. Online ahead of print. ABSTRACT As the key component of the complement system, C3 plays important roles in complement activation to regulate phagocytosis, lyse cells, mediate inflammation, and clear immune complexes. In the present study, CgC3 in the cell-free hemolymph of the Pacific oyster Crassostrea gigas was found … Read more