J Immunol. 2025 Apr 18:vkaf042. doi: 10.1093/jimmun/vkaf042. Online ahead of print. ABSTRACT Inflammasomes are multiprotein innate immune complexes formed in response to infections, tissue damage, or cellular stress that promote the maturation and release of IL-1β/IL-18 and are implicated in lytic cell death. The NLRP3 inflammasome is canonically activated by an initial priming event followed … Read more

J Immunol. 2025 Apr 17:vkaf036. doi: 10.1093/jimmun/vkaf036. Online ahead of print. ABSTRACT Natural killer (NK) cells are emerging as a promising tool for cancer immunotherapy due to their innate ability to selectively recognize and eliminate cancer cells. Over the past 3 decades, strategies to harness NK cells have included cytokines, small molecules, antibodies, and the … Read more

J Immunol. 2025 Apr 15:vkae040. doi: 10.1093/jimmun/vkae040. Online ahead of print. ABSTRACT In people living with human immunodeficiency virus (HIV, PLWH), the coronavirus disease 2019 (COVID-19) vaccine often results in a limited humoral immune response. While a reduced absolute CD4+ T cell count is a known factor, other determinants remain unclear. To investigate variables influencing … Read more

J Immunol. 2025 Apr 15:vkaf032. doi: 10.1093/jimmun/vkaf032. Online ahead of print. ABSTRACT Despite pigs being an important species in influenza A virus (IAV) epidemiology and a reliable preclinical model for human IAV infections, many aspects of the porcine pulmonary immune system remain poorly understood. Here, we characterized the single-cell landscape of lung leukocytes of healthy … Read more

J Immunol. 2025 Apr 15:vkaf040. doi: 10.1093/jimmun/vkaf040. Online ahead of print. ABSTRACT Inducible Co-Stimulator (ICOS), as a T-cell-specific costimulatory receptor that enhances T-cell responses to foreign antigens, plays a crucial role in cancer immunity. However, its role in MSS/pMMR colorectal cancer (CRC) remains unclear. In this study, we demonstrated that ICOS expression decreases as the … Read more

J Immunol. 2025 Apr 10:vkaf047. doi: 10.1093/jimmun/vkaf047. Online ahead of print. ABSTRACT Chimeric antigen receptor T (CART) cell therapy is an innovative form of immunotherapy that has shown remarkable and long-term responses in patients with B-cell malignancies. Over the years, the field has made significant progress in our understanding of the successes and challenges associated … Read more

J Immunol. 2025 Apr 10:vkaf016. doi: 10.1093/jimmun/vkaf016. Online ahead of print. ABSTRACT Insertion or deletion of one or two base pairs within a coding region causes a frameshift, which has the potential to generate neoepitopes (InDel-generated neoepitopes) that lack a self-counterpart and are entirely novel. Despite the obvious appeal of InDel-generated neoepitopes, and the demonstration … Read more

J Immunol. 2025 Apr 10:vkaf060. doi: 10.1093/jimmun/vkaf060. Online ahead of print. ABSTRACT Lung-resident conventional dendritic cells (cDCs) coordinate immune responses to respiratory viruses in the respiratory tract or after migration to mediastinal lymph nodes (mLN). Migratory DCs include cDC1s (CD103+XCR1+CD24hi) expressing IRF8 or cDC2s (CD11b+SIRPα+CD24+) expressing IRF4. IRF4+ cDC2s are divided into a CD24hi subset … Read more

J Immunol. 2025 Apr 9:vkaf031. doi: 10.1093/jimmun/vkaf031. Online ahead of print. ABSTRACT The cellular form of the prion protein (PrPC), known for its involvement as a misfolded isoform in transmissible spongiform encephalopathies, has recently been identified to exert a protective effect against viral infections. In this study, we explored the role of 2 other prion … Read more

J Immunol. 2025 Apr 9:vkaf034. doi: 10.1093/jimmun/vkaf034. Online ahead of print. ABSTRACT Imbalanced effector and regulatory CD4+ T cell subsets drive many inflammatory diseases. These T cell subsets rely on distinct metabolic programs, modulation of which differentially affects T cell fate and function. Lipid metabolism is fundamental yet remains poorly understood across CD4+ T cell … Read more