J Immunol. 2025 Apr 9:vkaf037. doi: 10.1093/jimmun/vkaf037. Online ahead of print. ABSTRACT Cytokine-induced killer (CIK) cells, as an adoptive immunotherapy, are effective at treating colorectal cancer (CRC). However, whether an individual can benefit from CIK cell therapy remains unclear. In this study, we analyzed the long-term effects of CIK cell therapy and specifically the relationship … Read more

J Immunol. 2025 Apr 8:vkaf030. doi: 10.1093/jimmun/vkaf030. Online ahead of print. ABSTRACT Studies support a role for natural killer (NK) cells in cancer control, making these cells attractive for immunotherapy. One method being tested to make effective NK cells is the ex vivo activation with interleukin (IL)-12, IL-15, and IL-18. We demonstrate that this induces … Read more

J Immunol. 2025 Apr 4:vkaf010. doi: 10.1093/jimmun/vkaf010. Online ahead of print. ABSTRACT Neutrophils are the first line of defense against pathogens, combating them by using several antimicrobial mechanisms. These cells display a remarkable plasticity that can be molded by the different environments that neutrophils confront to protect the host, therefore presenting diverse phenotypes. Actually, pro- … Read more

J Immunol. 2025 Apr 4:vkaf035. doi: 10.1093/jimmun/vkaf035. Online ahead of print. ABSTRACT Tissue-resident memory cells contribute to allergen-induced inflammation and airway hyperresponsiveness, but relatively little is known of the cellular and molecular mechanisms underlying the accumulation of these cells in the lung. Here, we show that allergen-specific CD4+ resident memory T cells are virtually absent … Read more

J Immunol. 2025 Apr 4:vkaf048. doi: 10.1093/jimmun/vkaf048. Online ahead of print. ABSTRACT T-cell central tolerance is controlled by thymocyte TCR recognition of self-peptides presented by thymic APCs. While thymic epithelial cells are essential for T-cell central tolerance, a variety of other traditional APCs also play critical roles in T-cell selection. Similar to how peripheral APCs … Read more

J Immunol. 2025 Apr 3:vkaf033. doi: 10.1093/jimmun/vkaf033. Online ahead of print. ABSTRACT This review provides a broad overview of lessons learned in the five years since COVID-19 was identified. It is a bimodal disease, starting with an initially virus-driven phase, followed by resolution or ensuing inappropriate immune activation causing severe inflammation that is no longer … Read more

J Immunol. 2025 Apr 3:vkaf041. doi: 10.1093/jimmun/vkaf041. Online ahead of print. ABSTRACT Natural killer (NK) cells are innate lymphocytes that exhibit adaptive traits particularly evident during cytomegalovirus (CMV) infection. Following mouse CMV (MCMV) infection, NK cells upregulate the transcription factors IRF4 and IRF8, which are indispensable for their survival and proliferation upon viral infection. However, … Read more

J Immunol. 2025 Apr 3:vkae025. doi: 10.1093/jimmun/vkae025. Online ahead of print. ABSTRACT Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease characterized by a wide range of clinical and immunologic manifestations, most prominently, the production of autoantibodies to nuclear components (ANAs). A previous study delineated four SLE patient clusters based on autoantibody expression to … Read more

J Immunol. 2025 Apr 3:vkaf045. doi: 10.1093/jimmun/vkaf045. Online ahead of print. ABSTRACT Interferon gamma (IFN-γ) is a pleotropic cytokine which is a central mediator of the immune response to pathogen infection, while also playing important roles in tumour suppression and the pathogenesis of various autoimmune diseases. Consequently, there is potential utility in the treatment of … Read more

J Immunol. 2025 Apr 2:vkae062. doi: 10.1093/jimmun/vkae062. Online ahead of print. ABSTRACT Although immune responses to bacillus Calmette-Guerin (BCG)-vaccination and susceptibility to pediatric tuberculosis (TB) vary across individuals, the underlying cellular mechanism regulating this heterogeneity is poorly understood. We used a nested case-control study with a 2-yr prospective observation period to examine whether genetic variation … Read more