J Immunol. 2024 Dec 15;213(12):1799-1810. doi: 10.4049/jimmunol.2400491. ABSTRACT Chimeric Ag receptor T cells derived from universal donors are susceptible to recipient immunologic rejection, which may limit their in vivo persistence and compromise treatment efficacy. In this study, we generated HLA class I-deficient T cells by disrupting β2-microglobulin to evade recognition by HLA-mismatched CD8+ T cells, … Read more

J Immunol. 2024 Dec 15;213(12):1729-1737. doi: 10.4049/jimmunol.2400033. ABSTRACT Dysregulation of lipid homeostasis causes the deposition of lipids in the form of tiny droplets within foamy macrophages (FMs). In FMs, host-derived lipids aid in survival of various intracellular pathogens leading to sustained infection. In several infectious diseases, the transformation of macrophages into a foamy phenotype is … Read more

J Immunol. 2024 Dec 1;213(11):1571. doi: 10.4049/jimmunol.2490017. NO ABSTRACT PMID:39556785 | DOI:10.4049/jimmunol.2490017

J Immunol. 2024 Dec 1;213(11):1573-1584. doi: 10.4049/jimmunol.2400447. ABSTRACT The family of IgG Abs is a crucial component of adaptive immunity. Glycosylation of IgG maintains its structural integrity and modulates its effector functions. In this review, we discuss IgG glycosylation covering cell biological as well as therapeutic and disease-related aspects, focusing on the glycan structures in … Read more

J Immunol. 2024 Nov 8:ji2400493. doi: 10.4049/jimmunol.2400493. Online ahead of print. ABSTRACT Ubiquitination is a critical posttranslational modification that regulates host immune responses to pathogens. In this study, we investigated the ubiquitination of hemocyanin (PvHMC [Penaeus vannamei hemocyanin]) mediated by the mitochondrial E3 ubiquitin ligase (PvMulan) in shrimp Penaeus vannamei. We characterized distinct ubiquitination patterns … Read more

J Immunol. 2024 Nov 6:ji2300818. doi: 10.4049/jimmunol.2300818. Online ahead of print. ABSTRACT Zebrafish (Danio rerio) are a compelling model for studying lymphocytes because zebrafish and humans have similar adaptive immune systems, including their lymphocytes. Antibodies that recognize zebrafish proteins are sparse, so many investigators use transgenic, lymphocyte-specific fluorophore-labeled lines. Human and zebrafish lymphocyte types are … Read more

J Immunol. 2024 Nov 6:ji2400607. doi: 10.4049/jimmunol.2400607. Online ahead of print. ABSTRACT Rowe, A. M., H. Yun, B. R. Treat, P. R. Kinchington, and R. L. Hendricks. 2017. Subclinical herpes simplex virus type 1 infections provide site-specific resistance to an unrelated pathogen. J. Immunol. 198: 1706-1717. The second author’s first name was published incorrectly. The … Read more

J Immunol. 2024 Nov 15;213(10):1403. doi: 10.4049/jimmunol.2490016. NO ABSTRACT PMID:39495901 | DOI:10.4049/jimmunol.2490016

J Immunol. 2024 Nov 15;213(10):1407-1413. doi: 10.4049/jimmunol.2300670. ABSTRACT The aging population is increasing worldwide, and there is also an increase in the aging population living with overweight and obesity, due to changes in lifestyle and in dietary patterns that elderly individuals experience later in life. Both aging and obesity are conditions of accelerated metabolic dysfunction … Read more

J Immunol. 2024 Nov 4:ji2400425. doi: 10.4049/jimmunol.2400425. Online ahead of print. ABSTRACT Envelope viruses are the most threatening pathogens to eukaryotes. The search for target genes against envelope viruses is particularly important. The activating transcription factors (ATFs) regulate cancer proliferation, maintain cellular redox homeostasis, extend biological longevity, and respond to viral stimuli. However, the mechanism … Read more