J Immunol. 2025 Nov 4:vkaf293. doi: 10.1093/jimmun/vkaf293. Online ahead of print. ABSTRACT Activation of natural killer (NK) cells by transformed targets requires the engagement of activating receptors and commonly a concomitant loss of inhibitory signaling. While the coactivating receptor DNAM-1 is involved in NK cell recognition of tumors expressing the nectin-like molecule CD155, in many … Read more

J Immunol. 2025 Nov 3:vkaf295. doi: 10.1093/jimmun/vkaf295. Online ahead of print. ABSTRACT Acute respiratory distress syndrome (ARDS) is a severe inflammatory lung disorder triggered by pneumonia, sepsis, trauma, and COVID-19, leading to high mortality. In this study, we investigated the effect of aryl hydrocarbon receptor (AhR) activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a potent ligand, on LPS-induced … Read more

J Immunol. 2025 Nov 2:vkaf284. doi: 10.1093/jimmun/vkaf284. Online ahead of print. ABSTRACT FcɛR1γ is a transmembrane adaptor protein that regulates the activating receptors NKp30, NKp46, and CD16 expression and function in human natural killer (NK) cells. HLA-E expression by cancer cells suppresses NK cell function through interaction with NKG2A. Here, we engineered human NK cells … Read more

J Immunol. 2025 Nov 1:vkaf289. doi: 10.1093/jimmun/vkaf289. Online ahead of print. ABSTRACT Dimethyl fumarate (DMF) is an oral therapy approved for the treatment of relapsing-remitting multiple sclerosis, and it is known to reduce disease severity in experimental autoimmune encephalomyelitis (EAE). Because self-reactive Th17 lymphocytes are thought to become activated in the gut before migrating to … Read more

J Immunol. 2025 Oct 31:vkaf250. doi: 10.1093/jimmun/vkaf250. Online ahead of print. ABSTRACT Cellular immunotherapy has revolutionized the treatment of hematologic malignancies yet has had limited success in the solid tumor microenvironment (TME). While insufficient nutrients can lead to T cell metabolic stress in the TME, the glutamine antagonist DON can paradoxically enhance antitumor immunity. Because … Read more

J Immunol. 2025 Oct 31:vkaf265. doi: 10.1093/jimmun/vkaf265. Online ahead of print. ABSTRACT Germinal centers (GCs) are specialized sites in lymphoid tissues where antigen-specific B cells undergo proliferation, affinity maturation, and differentiation into high-affinity memory B cells and long-lived plasma cells following immunization or infection. The specific signals and mechanisms that are involved in GC B … Read more

J Immunol. 2025 Oct 1;214(10):2523-2534. doi: 10.1093/jimmun/vkaf235. ABSTRACT Maternal immunity is critical for neonatal defense during early life, when infants are highly susceptible to infection. Antibodies transferred across the placenta or through breast milk not only provide immediate protection but also shape immune development. Defining the mechanisms and outcomes of this passive protection is essential … Read more

J Immunol. 2025 Oct 1;214(10):2494-2503. doi: 10.1093/jimmun/vkaf119. ABSTRACT While studies with laboratory rodent models have defined molecular and cellular components of the human immune system, experiments in these small mammals can’t capture all aspects of human immunity. This review focuses on immunologic research in large and agricultural species, highlighting how understanding immunity in a range … Read more

J Immunol. 2025 Oct 1;214(10):2515-2522. doi: 10.1093/jimmun/vkaf244. ABSTRACT Rodent models for evaluating new cancer immunotherapies often fail to fully recapitulate the complexity of immune interactions that occur in cancer patients. Companion dogs with spontaneously developing cancers more closely resemble humans immunologically than rodents. This resemblance results in part because their immune systems have been educated … Read more

J Immunol. 2025 Oct 1;214(10):2504-2514. doi: 10.1093/jimmun/vkaf231. ABSTRACT Infection of eastern North American woodchucks (Marmota monax) with woodchuck hepatitis virus (WHV) represents the most valuable immunopathogenic model of hepatitis type B that, like in humans, can advance stepwise from acute hepatitis to chronic hepatitis and hepatocellular carcinoma (HCC) or become self-resolving and persist as a … Read more