J Immunol. 2026 Apr 15;215(4):vkag045. doi: 10.1093/jimmun/vkag045. ABSTRACT Interleukin 2 (IL-2) is a cytokine secreted by activated T cells that plays a central role in T cell proliferation and differentiation. In this study, we identified MARCH2, an E3 ubiquitin ligase of the MARCH family, as a negative regulator of IL-2 receptor alpha (IL-2Rα). MARCH2 interacts … Read more
J Immunol. 2026 Apr 15;215(4):vkag049. doi: 10.1093/jimmun/vkag049. ABSTRACT Autoimmune disorders reduce quality of life and lifespan and can increase B cell lymphoma risk. The adaptor protein TRAF3 regulates B cell survival, activation, and differentiation by restraining signaling through Toll-like receptors, tumor necrosis factor (TNF) receptor superfamily members, and the B cell antigen receptor-pathways linked to … Read more
J Immunol. 2026 Apr 15;215(4):vkag037. doi: 10.1093/jimmun/vkag037. ABSTRACT Escherichia coli (E. coli) is a leading cause of invasive bacterial infections in humans. Pathogenic E. coli is not only the major etiological agent of enteric/diarrheal disease and urinary tract infections, but also among the most common causes of sepsis and meningitis. Caspase-8 is known to regulate … Read more
J Immunol. 2026 Apr 15;215(4):vkag041. doi: 10.1093/jimmun/vkag041. ABSTRACT Riemerella anatipestifer infection causes septicemia and polyserositis in poultry, leading to serious economic losses to the global poultry industry. The ability to break through the host complement defense barrier is an important characteristic of R. anatipestifer. However, the underlying mechanisms are still not well understood at present. … Read more
J Immunol. 2026 Apr 15;215(4):vkag035. doi: 10.1093/jimmun/vkag035. ABSTRACT The importance of NAD metabolism in T cell differentiation and function has gained attention in recent years. However, technical limitations impede the specific interrogation of NAD dynamics in living immune cells. In this report, we present the redox index and capacity analysis (RICA) assay, a novel technique … Read more
J Immunol. 2026 Apr 15;215(4):vkaf371. doi: 10.1093/jimmun/vkaf371. ABSTRACT The immune environment at the maternal-fetal interface is highly regulated and changes depending on the stage of pregnancy. Any dysregulation or imbalance of the pro- and anti-inflammatory stages can disrupt placental development and can lead to various obstetric disorders, such as miscarriage, preterm birth, and preeclampsia. Several … Read more
J Immunol. 2026 Apr 15;215(4):vkag080. doi: 10.1093/jimmun/vkag080. ABSTRACT The Modular Immune In vitro Construct (MIMIC) system is an established laboratory-based methodology that reproduces in vitro the human in vivo T-cell immune response. In this study, we utilized the MIMIC system to establish a dendritic cell and CD4+ T-cell co-culture model that recapitulates T helper cell … Read more
J Immunol. 2026 Apr 15;215(4):vkag005. doi: 10.1093/jimmun/vkag005. ABSTRACT In this study, we investigate the mechanisms by which ischemia-free liver transplantation (IFLT) mitigates ischemia-reperfusion injury (IRI) and identify key therapeutic targets. Clinical data from 200 patients were collected to evaluate perioperative recovery and overall outcomes. Liver tissues were obtained from donors at the preprocurement, end-of-preservation, and … Read more
J Immunol. 2026 Apr 15;215(4):vkag063. doi: 10.1093/jimmun/vkag063. ABSTRACT The concept of polyfunctional secretion, the ability of cells to secrete multiple, functionally distinct proteins, has received increased attention for B cells as they have been described to secrete both antibodies and cytokines. However, the functional analysis of B cells was mostly performed in bulk, and consequently, … Read more
J Immunol. 2026 Apr 15;215(4):vkag054. doi: 10.1093/jimmun/vkag054. ABSTRACT Memory B cells (MBCs) are an integral part of the humoral immune response with the capacity to both reseed germinal center reactions and rapidly form antibody-secreting plasma cells (ASCs) upon secondary antigen encounter. MBCs arise via both T cell-dependent and -independent routes and while CD4+ T cells … Read more
