The Journal of Immunology

J Immunol. 2025 Apr 3:vkaf041. doi: 10.1093/jimmun/vkaf041. Online ahead of print. ABSTRACT Natural killer (NK) cells are innate lymphocytes that exhibit adaptive traits particularly evident during cytomegalovirus (CMV) infection. Following mouse CMV (MCMV) infection, NK cells upregulate the transcription factors IRF4 and IRF8, which are indispensable for their survival and proliferation upon viral infection. However, … Read more

J Immunol. 2025 Apr 3:vkae025. doi: 10.1093/jimmun/vkae025. Online ahead of print. ABSTRACT Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease characterized by a wide range of clinical and immunologic manifestations, most prominently, the production of autoantibodies to nuclear components (ANAs). A previous study delineated four SLE patient clusters based on autoantibody expression to … Read more

J Immunol. 2025 Apr 3:vkaf045. doi: 10.1093/jimmun/vkaf045. Online ahead of print. ABSTRACT Interferon gamma (IFN-γ) is a pleotropic cytokine which is a central mediator of the immune response to pathogen infection, while also playing important roles in tumour suppression and the pathogenesis of various autoimmune diseases. Consequently, there is potential utility in the treatment of … Read more

J Immunol. 2025 Apr 2:vkae062. doi: 10.1093/jimmun/vkae062. Online ahead of print. ABSTRACT Although immune responses to bacillus Calmette-Guerin (BCG)-vaccination and susceptibility to pediatric tuberculosis (TB) vary across individuals, the underlying cellular mechanism regulating this heterogeneity is poorly understood. We used a nested case-control study with a 2-yr prospective observation period to examine whether genetic variation … Read more

J Immunol. 2025 Apr 2:vkaf039. doi: 10.1093/jimmun/vkaf039. Online ahead of print. ABSTRACT Murine cytomegalovirus (MCMV) respiratory dissemination schemes, which mimic natural infection routes, have only recently become an area of investigation. Using an intratracheal (i.t.) infection method, we discovered that the respiratory infection route yields differential infection kinetics compared to the widely used intraperitoneal (i.p.) … Read more

J Immunol. 2025 Apr 1:vkaf017. doi: 10.1093/jimmun/vkaf017. Online ahead of print. ABSTRACT Follicular dendritic cells (FDCs) retain Ag-containing immune complexes (ICs), facilitate the selection of high-affinity antibodies, and protect B cells in germinal centers (GCs) from apoptosis. In systemic lupus erythematosus patients, apoptotic debris is found on the surface of FDCs. However, the mechanisms by … Read more

J Immunol. 2025 Apr 1:vkaf007. doi: 10.1093/jimmun/vkaf007. Online ahead of print. ABSTRACT Establishing the magnitude and kinetics of polyclonal Ag-specific CD8 T-cell responses, in addition to their functional fitness, is critical for evaluating a host’s ability to respond to different kinds of infections and/or immunizations. To track CD8 T-cell responses during infection, a surrogate-activation-marker approach … Read more

J Immunol. 2025 Mar 31:vkae059. doi: 10.1093/jimmun/vkae059. Online ahead of print. ABSTRACT Active immune suppression can mediate the balance between protective cellular immunity and harmful immunopathology. This suppression can occur locally, at an infection site, or in regional draining lymph nodes (dLNs). Immune regulation is of particular importance in sites such as the lung where … Read more

J Immunol. 2025 Mar 12:vkae020. doi: 10.1093/jimmun/vkae020. Online ahead of print. ABSTRACT Autoimmune disease refers to a condition when the immune system anomalously attacks its own body and healthy cells. Although the exact causes of autoimmune diseases are unknown, it is recognized that excessive or aberrant cytokine responses contribute significantly to the development of autoimmunity. … Read more

J Immunol. 2025 Mar 28:vkaf027. doi: 10.1093/jimmun/vkaf027. Online ahead of print. ABSTRACT Macrophages and natural killer (NK) cells can effectively kill tumor cells in the presence of anti-cancer IgG monoclonal antibodies (mAbs), but neutrophils are less effective. We previously showed that IgG1 bispecific antibodies (BsAb), which target the IgA Fc receptor (FcαRI, CD89) and a … Read more