The Journal of Immunology

J Immunol. 2025 Mar 22:vkaf020. doi: 10.1093/jimmun/vkaf020. Online ahead of print. ABSTRACT Galectins are expressed by different immune and nonimmune cells with diverse immunomodulatory properties. However, their roles in erythropoiesis remain unknown. We investigated the expression of galectin genes in splenic CD71+ erythroid cells (CECs) from neonatal BALB/c mice at various developmental stages using bulk … Read more

J Immunol. 2025 Mar 22:vkaf019. doi: 10.1093/jimmun/vkaf019. Online ahead of print. ABSTRACT Major depression disorder is a common illness that severely limits psychosocial functioning, affects outcomes of other diseases, and diminishes the quality of life. High-salt diet (HSD) has long been closely associated with the occurrence and development of depression, but whether or how HSD … Read more

J Immunol. 2025 Mar 21:vkaf008. doi: 10.1093/jimmun/vkaf008. Online ahead of print. ABSTRACT Therapeutic B cell depletion with monoclonal antibodies targeting CD20 forced a rethink about the pathogenic role of B cells and plasma cells in autoimmune diseases; however, it was tempered by frequent clinical relapses or nonresponse to CD20-directed therapy. Here, we re-evaluate B cell … Read more

J Immunol. 2025 Mar 21:vkaf018. doi: 10.1093/jimmun/vkaf018. Online ahead of print. ABSTRACT HIF1β, which serves as a common binding partner of the aryl hydrocarbon receptor and hypoxia-inducible factor (HIF)-α subunits, plays a key role in 2 cellular signaling pathways: the aryl hydrocarbon receptor and HIF pathways. Whether HIF1β is involved in antiviral innate immunity remains … Read more

J Immunol. 2025 Mar 20:vkae065. doi: 10.1093/jimmun/vkae065. Online ahead of print. ABSTRACT Endometrial stromal cells acquire a secretory profile associated with endoplasmic reticulum stress (ERS) and unfolded protein response (UPR) related to the onset of a sterile inflammatory response essential for sustaining embryo implantation. However, exacerbated stromal ERS/UPR is associated with reproductive complications. Given the … Read more

J Immunol. 2025 Mar 20:vkaf021. doi: 10.1093/jimmun/vkaf021. Online ahead of print. ABSTRACT Although the importance of the unique member of S100 EF-hand family, S100A10 in health and disease is well appreciated, a precise characterization of S100A10 expression still remains elusive. To this purpose, we generated a knock-in mouse line in which downstream of the coding … Read more

J Immunol. 2025 Mar 19:vkae064. doi: 10.1093/jimmun/vkae064. Online ahead of print. ABSTRACT Regulatory T cells (Tregs) mediate tissue homeostasis and repair. The function of the interleukin-7 receptor α (IL-7Rα) in nonlymphoid tissue Tregs is still unknown, although low expression of IL-7Rα is a widely accepted marker for Tregs. Here, we show that IL-33R (ST2)-expressing Tregs … Read more

J Immunol. 2025 Mar 19:vkaf025. doi: 10.1093/jimmun/vkaf025. Online ahead of print. NO ABSTRACT PMID:40107285 | DOI:10.1093/jimmun/vkaf025

J Immunol. 2025 Mar 18:vkae055. doi: 10.1093/jimmun/vkae055. Online ahead of print. ABSTRACT Antisense oligonucleotides (ASOs) are a new class of single-stranded DNA-based drugs that hold great therapeutic potential. A low incidence of severe, dose-dependent, and reversible thrombocytopenia (TCP) (platelets < 50 K/μl) has been reported in nonhuman primate (NHP) populations, following treatment of monkeys with … Read more

J Immunol. 2025 Mar 18:vkae061. doi: 10.1093/jimmun/vkae061. Online ahead of print. ABSTRACT Staphylococcus aureus is a commensal and opportunist pathogen of the upper respiratory tract. The recognition of pathogen-associated molecular patterns through pattern-recognition receptors is crucial for eliminating microorganisms such as S. aureus. DC-SIGN (CD209) is a pattern-recognition receptor that binds to a broad range … Read more