The Journal of Immunology

J Immunol. 2025 Mar 18:vkae053. doi: 10.1093/jimmun/vkae053. Online ahead of print. ABSTRACT Respiratory viral infections are a major contributor to mortality in children under 5 years of age, and disproportionately affect preterm neonates. Previously, using our established 3-day-old neonatal murine model of influenza virus infection, we demonstrated that treatment of neonatal mice with intranasal Lactobacillus … Read more

J Immunol. 2025 Mar 18:vkaf006. doi: 10.1093/jimmun/vkaf006. Online ahead of print. ABSTRACT Dysregulated innate immune responses contribute to multisystem inflammatory syndrome in children (MIS-C), characterized by gastrointestinal, mucocutaneous, and/or cardiovascular injury occurring weeks after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposure. To investigate innate immune functions, we stimulated ex vivo peripheral blood cells from … Read more

J Immunol. 2025 Mar 17:vkae047. doi: 10.1093/jimmun/vkae047. Online ahead of print. ABSTRACT Killer cell immunoglobulin-like receptors (KIRs) are key modulators of natural killer cell activity, displaying either activating or inhibitory potential upon recognition of major histocompatibility complex (MHC) class I molecules. The genomic organization of KIR genes is complex, involving copy number variation and allelic … Read more

J Immunol. 2025 Mar 17:vkae045. doi: 10.1093/jimmun/vkae045. Online ahead of print. ABSTRACT The cytokine IL-2 plays a pivotal role in the immune system, specifically in the proliferation of T, B, and NK cells. The alpha subunit of the IL-2 receptor, IL-2Rα (CD25), is known to regulate the expansion and differentiation of T lymphocytes. CD25 is … Read more

J Immunol. 2025 Mar 17:vkaf044. doi: 10.1093/jimmun/vkaf044. Online ahead of print. NO ABSTRACT PMID:40096641 | DOI:10.1093/jimmun/vkaf044

J Immunol. 2025 Mar 17:vkaf024. doi: 10.1093/jimmun/vkaf024. Online ahead of print. ABSTRACT The prevalence of obesity and metabolic diseases have risen significantly over the past decades. Chronic inflammation in obesity is a link between obesity and secondary disease. While macrophages and monocytes are known to contribute to metabolic disease risk during diet exposure, little is … Read more

J Immunol. 2025 Mar 14:vkaf005. doi: 10.1093/jimmun/vkaf005. Online ahead of print. ABSTRACT Burkitt lymphoma (BL) is characterized by elevated levels of the enzyme activation-induced cytidine deaminase (AID), an enzyme critical for MYC translocation that is the hallmark of BL. Both EBV and Plasmodium falciparum malaria are cofactors in the etiology of BL. However, how these … Read more

J Immunol. 2025 Mar 14:vkae068. doi: 10.1093/jimmun/vkae068. Online ahead of print. ABSTRACT The virtually monomorphic antigen presentation molecule HLA-E can present self- and non-self peptides to the NKG2A/CD94 co-receptor inhibitory complex expressed on natural killer (NK) cells and to T cell receptors (TCRs) expressed on T cells. HLA-E presents self-peptides to NKG2A/CD94 to regulate tissue … Read more

J Immunol. 2025 Mar 13:vkaf001. doi: 10.1093/jimmun/vkaf001. Online ahead of print. ABSTRACT Type 1 innate lymphoid cells (ILC1s) respond to infections and tumors by producing IFN-γ. Although RAR-related orphan receptor α (RORα) is required for ILC2s and some ILC3s, its role in ILC1 development remains controversial. To investigate the role of RORα in ILC1s, we … Read more

J Immunol. 2025 Jan 1;214(1):104-114. doi: 10.1093/jimmun/vkae013. ABSTRACT Current influenza vaccines are not effective in conferring protection against antigenic variants and pandemics. To improve cross-protection of influenza vaccination, we developed a 5xM2e messenger RNA (mRNA) vaccine encoding the tandem repeat conserved ectodomain (M2e) of ion channel protein M2 derived from human, swine, and avian influenza … Read more