The Journal of Immunology

J Immunol. 2026 Apr 15;215(4):vkag050. doi: 10.1093/jimmun/vkag050. ABSTRACT Group 3 innate lymphoid cells (ILC3s) preserve intestinal barrier integrity by producing IL-22 and IL-17A, yet the molecular mechanisms that maintain these cytokines during inflammation are incompletely defined. Here, we identify DAB2IP as a cell-intrinsic regulator of ILC3 effector function. In human inflammatory bowel disease mucosa, DAB2IP … Read more

J Immunol. 2026 Apr 15;215(4):vkag019. doi: 10.1093/jimmun/vkag019. ABSTRACT T cell immunity depends on the precise coordination of signaling networks with actin cytoskeleton remodeling, yet the molecular regulators of these processes remain incompletely defined. Flightless-1 (FLII) is a gelsolin-family actin regulator with unique leucine-rich repeats that can couple cytoskeletal dynamics to diverse signaling pathways. Here, using … Read more

J Immunol. 2026 Apr 15;215(4):vkag011. doi: 10.1093/jimmun/vkag011. ABSTRACT At the heart of Lyon, France, two leading institutes, the Centre International de Recherche en Infectiologie and the Cancer Research Center of Lyon, have built strong immunology programs since their establishment in the early 2010s. Their collaborative spirit led to the creation of the Immune Responses in … Read more

J Immunol. 2026 Apr 15;215(4):vkag059. doi: 10.1093/jimmun/vkag059. ABSTRACT Myelodysplastic syndrome (MDS) is a heterogeneous group of myeloid neoplasms characterized by treatment difficulties and a propensity to progress to acute myeloid leukemia. Impaired natural killer (NK) cell surveillance is a hallmark of MDS, yet the underlying molecular mechanisms remain poorly understood. This study aims to elucidate … Read more

J Immunol. 2026 Apr 15;215(4):vkag058. doi: 10.1093/jimmun/vkag058. ABSTRACT Peritoneal cavity (PerC) B cells can be classified into distinct subpopulations; however, their differential antigen-presenting capabilities and roles in antitumor immune responses remain largely unexplored. This study aimed to elucidate the properties of PerC B cell subpopulations in antitumor immune responses by using ovalbumin (OVA) peptides as … Read more

J Immunol. 2026 Apr 15;215(4):vkag038. doi: 10.1093/jimmun/vkag038. ABSTRACT T cells utilize diverse T cell receptors (TCRs) to recognize antigenic peptides and mediate adaptive immunity. However, the organization and function of αβ T cells in early vertebrates remain poorly understood. Here, we systematically characterized the TCRα locus and αβ T cell responses in Nile tilapia (Oreochromis … Read more

J Immunol. 2026 Apr 15;215(4):vkag062. doi: 10.1093/jimmun/vkag062. ABSTRACT CD8+ T-cell differentiation during chronic viral infection is supported by metabolic reprogramming to meet distinct bioenergetic demands. Early effector CD8+ T-cell differentiation and function are supported by the PI3K-Akt-mTOR pathway, while the differentiation of late exhausted CD8+ T cells remains incompletely understood. We first characterized the metabolic … Read more

J Immunol. 2026 Apr 15;215(4):vkag040. doi: 10.1093/jimmun/vkag040. ABSTRACT TLR20 is a teleost-specific TLR member. However, its species distribution, biological function, and underlying mechanism remain largely unknown. In this study, we systematically retrieved the TLR20 species distribution and found only a few teleosts contain different TLR20 variants, especially in Cyprinidae. Subsequently, we employed an economically important … Read more

J Immunol. 2026 Apr 15;215(4):vkag067. doi: 10.1093/jimmun/vkag067. ABSTRACT Negative regulators are crucial for maintaining immune homeostasis, yet the complexities of their regulatory mechanisms are not fully elucidated. In this study, we reveal that IGF2BP2, an m6A reader protein, orchestrates the formation of phase-separated condensates dependent on G3BP1, acting as a pivotal negative regulator of bacterial-induced … Read more

J Immunol. 2026 Apr 15;215(4):vkag056. doi: 10.1093/jimmun/vkag056. ABSTRACT Current immunotherapies for autoimmune diseases lack sufficient specificity and often compromise protective immunity, underscoring the need for precision-based approaches. Here, we identify x-mAb, a germline-encoded IgM autoantibody derived from dual-expresser lymphocytes of patients with type 1 diabetes (T1D), as a potent agent for precision immunotherapy. In the … Read more