J Immunol. 2025 Oct 3:vkaf224. doi: 10.1093/jimmun/vkaf224. Online ahead of print. ABSTRACT Head and neck squamous cell carcinoma (HNSCC) constitutes 90% of head and neck cancers. HNSCC development is linked to chronic inflammation, while established HNSCC tumors are often immune suppressive. However, both occur through mechanisms that are not fully understood. The cytosolic double-stranded DNA … Read more
J Immunol. 2025 Oct 3:vkaf233. doi: 10.1093/jimmun/vkaf233. Online ahead of print. ABSTRACT Fibroblasts participate in inflammatory responses and play a critical role in the switch from acute to persistent inflammation. Whether fibroblast responses are modulated by signals from their microenvironment is not well established. Insulin signaling and insulin resistance modulate responsiveness of innate immune cells … Read more
J Immunol. 2025 Oct 1:vkaf223. doi: 10.1093/jimmun/vkaf223. Online ahead of print. ABSTRACT Systemic lupus erythematosus is characterized by activation of many self-reactive B cell clones that produce autoantibodies. This can be modeled using mixed bone marrow chimeras, where autoreactive 564Igi B cells initiate autoimmunity that spreads to wild-type (WT) B cells. The mechanisms controlling the … Read more
J Immunol. 2025 Sep 1;214(9):2135-2137. doi: 10.1093/jimmun/vkaf178. NO ABSTRACT PMID:41024741 | DOI:10.1093/jimmun/vkaf178
J Immunol. 2025 Sep 30:vkaf266. doi: 10.1093/jimmun/vkaf266. Online ahead of print. ABSTRACT Mucosa-associated invariant T (MAIT) cells are innate-like T cells abundant in mucosal tissues, liver, and blood. MAIT cells recognize riboflavin metabolite-derived microbial antigens displayed by the MHC-I-related protein (MR1) and respond by producing cytokines, killing infected cells, and suppressing microbial growth. We previously … Read more
J Immunol. 2025 Sep 29:vkaf228. doi: 10.1093/jimmun/vkaf228. Online ahead of print. ABSTRACT Hepatocellular carcinoma (HCC) stands as one of the most prevalent and fatal malignancies globally, posing a persistent challenge in its treatment due to immune evasion. We knocked down MEF2D in HCC cell lines and analyzed HCC tissues and cell lines by RNA sequencing, … Read more
J Immunol. 2025 Sep 27:vkaf240. doi: 10.1093/jimmun/vkaf240. Online ahead of print. ABSTRACT Matrix metalloproteinase 9 (MMP-9) plays a key role in the pathogenesis of inflammatory diseases and is upregulated by TNF-α. ITE (2-[1’H-indole-3′-carbonyl]-thiazole-4-carboxylic acid methyl ester) functions as an endogenous ligand for the aryl hydrocarbon receptor and is involved in inflammation. It is still uncertain … Read more
J Immunol. 2025 Sep 27:vkaf254. doi: 10.1093/jimmun/vkaf254. Online ahead of print. ABSTRACT Foxp3+ regulatory T (Treg) cells with antigen receptors (TCRs) specific for host peptides suppress autoimmunity. Paradoxically, Treg cells are also found in CD4+ T-cell populations specific for foreign (nonhost) peptides. We investigated the origin and function of these Treg cells in mice. Populations … Read more
J Immunol. 2025 Sep 26:vkaf252. doi: 10.1093/jimmun/vkaf252. Online ahead of print. ABSTRACT Tuberculosis (TB), a significant global health issue, needs novel therapeutic approaches to reduce its burden. Studying host-pathogen interactions provides new targets for host-directed therapeutics (HDTs). Nuclear receptors (NRs) are important master regulators of cellular function and bona fide drug targets. Herein, we identify … Read more
J Immunol. 2025 Sep 26:vkaf259. doi: 10.1093/jimmun/vkaf259. Online ahead of print. ABSTRACT Tumor-infiltrating lymphocyte (TIL) therapy is a type of adoptive immunotherapy potentially applicable to many types of solid tumors. Although gynecologic malignancies are promising targets for TIL therapy, its objective efficacy has not been established. Current TIL culture typically involves incubation of dissociated samples … Read more
