Trends in Immunology

Trends Immunol. 2025 Jan 23:S1471-4906(24)00308-9. doi: 10.1016/j.it.2024.12.006. Online ahead of print. ABSTRACT Ovarian cancer (OC) is the most lethal gynecologic malignancy, characterized by multiple histological subtypes, each with distinct pathological and clinical features. Current treatment approaches include cytotoxic chemotherapies, poly(ADP-ribose) polymerase (PARP) inhibitors, bevacizumab, hormonal therapy, immunotherapy, and antibody-drug conjugates (ADCs). In this review we … Read more

Trends Immunol. 2025 Jan 21:S1471-4906(24)00307-7. doi: 10.1016/j.it.2024.12.005. Online ahead of print. ABSTRACT Conventional dendritic cells (cDCs) are sentinels of the mammalian immune system that sense a wide range of danger and homeostatic signals to induce appropriately targeted T cell immune responses. Traditionally classified into two main subsets, cDC1 and cDC2, recent research shows that cDC2s … Read more

Trends Immunol. 2025 Jan 21:S1471-4906(24)00306-5. doi: 10.1016/j.it.2024.12.004. Online ahead of print. ABSTRACT Community engagement is essential for shaping equitable biomedical research priorities, but it is often underutilized, especially for marginalized populations. To integrate community feedback from the public into research, herein we describe a collaborative pilot funded by the Chan Zuckerberg Initiative which pairs the … Read more

Trends Immunol. 2025 Jan 7:S1471-4906(24)00305-3. doi: 10.1016/j.it.2024.12.003. Online ahead of print. NO ABSTRACT PMID:39779379 | DOI:10.1016/j.it.2024.12.003

Trends Immunol. 2024 Dec 27:S1471-4906(24)00299-0. doi: 10.1016/j.it.2024.11.014. Online ahead of print. ABSTRACT Immune checkpoint inhibitors (ICIs) have transformed cancer treatment but are frequently associated with immune-related adverse events (irAEs). This article offers a novel synthesis of findings from both preclinical and clinical studies, focusing on the molecular mechanisms driving irAEs across diverse organ systems. It … Read more

Trends Immunol. 2024 Dec 27:S1471-4906(24)00297-7. doi: 10.1016/j.it.2024.11.012. Online ahead of print. ABSTRACT Diverse macrophage populations inhabit the rodent and human central nervous system (CNS), including microglia in the parenchyma and border-associated macrophages (BAMs) in the meninges, choroid plexus, and perivascular spaces. These innate immune phagocytes are essential in brain development and maintaining homeostasis, but they … Read more

Trends Immunol. 2024 Dec 27:S1471-4906(24)00303-X. doi: 10.1016/j.it.2024.12.001. Online ahead of print. ABSTRACT Generalized pustular psoriasis (GPP) is a rare human autoinflammatory disorder with life-threatening systemic effects. Keratinocyte-derived interleukin (IL)-36 signaling has been identified as a key mediator of immune response in the skin of affected individuals. Recognition of various mutations along the IL-36 axis and … Read more

Trends Immunol. 2024 Dec 24:S1471-4906(24)00304-1. doi: 10.1016/j.it.2024.12.002. Online ahead of print. ABSTRACT Tumor-initiating cells (TICs) are particularly efficient at evading detection and elimination by the human immune system. Recent data from Yang and collaborators demonstrate that – at least in preclinical hepatocellular carcinoma models – the immunological privilege of CD49f+ TICs can be limited by … Read more

Trends Immunol. 2024 Dec 20:S1471-4906(24)00296-5. doi: 10.1016/j.it.2024.11.011. Online ahead of print. ABSTRACT When B cells engage in an immune response, metabolic reprogramming is key to meeting cellular energetic and biosynthetic demands. Epstein-Barr virus (EBV) is a highly prevalent gamma-herpesvirus, latently infecting B cells for the human host’s lifetime. By hijacking signaling pathways of T cell-dependent … Read more

Trends Immunol. 2024 Dec 16:S1471-4906(24)00298-9. doi: 10.1016/j.it.2024.11.013. Online ahead of print. ABSTRACT Laboratory mice housed under specific pathogen-free (SPF) conditions are the standard model in biomedical research. However, experiments with a particular inbred mouse strain performed in different laboratories often yield inconsistent or conflicting data due to housing-specific variations in the composition and diversity of … Read more