Trends Immunol. 2024 Sep 26:S1471-4906(24)00215-1. doi: 10.1016/j.it.2024.09.007. Online ahead of print. ABSTRACT The recent study by Ryu et al. demonstrates that the SARS-CoV-2 Spike protein binds fibrin(ogen), impacting coagulation and immune responses in mice. In this spotlight article we focus on the described effects on natural killer (NK) cell responses as well as the suggested … Read more
Trends Immunol. 2024 Sep 25:S1471-4906(24)00214-X. doi: 10.1016/j.it.2024.09.006. Online ahead of print. ABSTRACT Extrahepatic, cell-autonomous, and/or intracellularly active complement components are increasingly recognized as key orchestrators of cell physiological processes. A recent study by Scott-Hewitt et al. demonstrates that microglia-derived C1q unexpectedly associates with the ribosomes of neurons in the aging murine brain, where it impacts … Read more
Trends Immunol. 2024 Sep 25:S1471-4906(24)00213-8. doi: 10.1016/j.it.2024.09.005. Online ahead of print. ABSTRACT Cancers hijack the nervous system for growth and spread. Thus, disrupting neuron-cancer crosstalk holds promise for blocking metastasis. Recently, Padmanaban et al. reported new therapeutic targets and showed that breast cancer cells activate sensory neurons to secrete the neuropeptide substance P (SP), leading … Read more
Trends Immunol. 2024 Sep 25:S1471-4906(24)00211-4. doi: 10.1016/j.it.2024.09.003. Online ahead of print. ABSTRACT Thromboinflammation is a peculiar and key component of acute COVID-19 pathogenesis, which contributes to long COVID. In a recent study, Ryu et al. demonstrate that the SARS-CoV-2 spike protein interacts with fibrinogen, promoting fibrin polymerization and its inflammatory activity. Targeting the inflammatory fibrin … Read more
Basophils, rare granulocytes, have long been acknowledged for their roles in type 2 immune responses. However, the mechanisms by which basophils adapt their functions to diverse mammalian microenvironments remain unclear. Recent advancements in specific research tools and single-cell-based technologies have greatly enhanced our understanding of basophils. Several studies have shown that basophils play a role in maintaining homeostasis but can also contribute to pathology in various tissues and…
