Trends Immunol. 2025 Feb 25:S1471-4906(25)00027-4. doi: 10.1016/j.it.2025.01.009. Online ahead of print. ABSTRACT Helper innate lymphoid cells (ILCs), comprising groups ILC1, ILC2, and ILC3, possess unique advantages in eliciting rapid immune responses and were recently found to exhibit direct tumor-killing capacities comparable with those of cytotoxic ILCs [natural killer (NK) cells] in humans and mice. Although … Read more
Trends Immunol. 2025 Feb 25:S1471-4906(25)00030-4. doi: 10.1016/j.it.2025.02.003. Online ahead of print. ABSTRACT Osteoimmunology is an interdisciplinary branch of immunology studying bidirectional interactions between the immune and skeletal systems. Bone marrow is vital for the production of immune cells and is implicated in multiple diseases across all immunology disciplines. Here, we briefly discuss recent progress from … Read more
Trends Immunol. 2025 Feb 20:S1471-4906(25)00025-0. doi: 10.1016/j.it.2025.01.007. Online ahead of print. ABSTRACT Fevers are an ancient feature of the inflammatory microenvironment. While fevers may improve the immune response to pathogens, mechanisms are unclear. We explore recent studies of how fever-range temperatures inform mammalian T cell metabolism, differentiation, and stress responses. Recent evidence indicates that metabolic … Read more
Trends Immunol. 2025 Feb 15:S1471-4906(25)00028-6. doi: 10.1016/j.it.2025.02.001. Online ahead of print. NO ABSTRACT PMID:39956713 | DOI:10.1016/j.it.2025.02.001
Trends Immunol. 2025 Feb 12:S1471-4906(24)00309-0. doi: 10.1016/j.it.2024.12.007. Online ahead of print. ABSTRACT Decidual stromal cells (DSCs) are involved in immunoregulatory mechanisms that prevent fetal rejection by the mammalian maternal immune system. Recent studies using single-cell RNA sequencing demonstrated the existence of different types of human and mouse DSCs, highlighting corresponding differentiation (decidualization) pathways, and suggesting … Read more
Trends Immunol. 2025 Jan 30:S1471-4906(25)00021-3. doi: 10.1016/j.it.2025.01.003. Online ahead of print. ABSTRACT The adaptor protein mitochondrial antiviral signaling protein (MAVS)-mediated innate immune response is essential for host defense against RNA viruses. Gokhale and colleagues report that cellular mRNAs assemble and activate the MAVS signalosome by directly binding to MAVS and regulating its interactors, consequently enhancing … Read more
Trends Immunol. 2025 Jan 30:S1471-4906(25)00001-8. doi: 10.1016/j.it.2025.01.001. Online ahead of print. ABSTRACT Tumor-infiltrating regulatory T (TI-Treg) cells constitute key components within the tumor microenvironment (TME) to suppress antitumor immunity and facilitate tumor progression. Although multiple therapies have been developed to eliminate TI-Treg cells, most of them exhibit only modest efficacy and harbor risks of inducing … Read more
Trends Immunol. 2025 Jan 28:S1471-4906(25)00022-5. doi: 10.1016/j.it.2025.01.004. Online ahead of print. ABSTRACT Mayassi and colleagues utilized spatial transcriptomics to create a comprehensive blueprint of the mouse gut, exploring its adaptability and resilience under perturbed conditions. Their work highlights the adaptive capabilities of the murine gut’s regionalized structure, providing insights into how it functions in a … Read more
Trends Immunol. 2025 Jan 27:S1471-4906(25)00002-X. doi: 10.1016/j.it.2025.01.002. Online ahead of print. ABSTRACT Chronic inflammatory diseases show significant heterogeneity in their phenotypes, with diverse immune cells and mediators interacting in response to various stimuli. This review proposes the concept of the ‘inflammazone’ framework – which maps the distribution of immune components driving disease pathogenesis – using … Read more
Trends Immunol. 2025 Jan 27:S1471-4906(25)00023-7. doi: 10.1016/j.it.2025.01.005. Online ahead of print. ABSTRACT Lim and colleagues demonstrate that synNotch transcriptional circuits engineered into T cells can be used to precisely control location-specific expression of payloads responding to antigen triggers, thus locally inhibiting unwanted immunity or neuroinflammation. With no off-tumor toxicity or systemic immunosuppression upon elimination of … Read more
