Trends in Immunology

Trends Immunol. 2024 Oct 17:S1471-4906(24)00221-7. doi: 10.1016/j.it.2024.09.013. Online ahead of print. ABSTRACT Cholesterol metabolites, particularly oxidized forms known as oxysterols, play crucial roles in modulating immune and metabolic processes across various tissues. Concentrations of local cholesterol and its metabolites influence tissue-specific immune responses by shaping the metabolic and spatial organization of immune cells in barrier … Read more

Trends Immunol. 2024 Oct 11:S1471-4906(24)00247-3. doi: 10.1016/j.it.2024.10.001. Online ahead of print. ABSTRACT Gao, Kim, and colleagues recently reported that clonal populations of CD4+ T cells could be detected in mice that underwent spinal cord injury (SCI). A subset of clones mediated enhanced motor recovery and suppressed inflammation. Further studies may point towards novel cell therapies … Read more

Trends Immunol. 2024 Oct 10:S1471-4906(24)00217-5. doi: 10.1016/j.it.2024.09.009. Online ahead of print. ABSTRACT The development of mammalian adaptive (i.e., B and T cell-mediated) immune responses is tightly controlled at transcriptional, epigenetic, and metabolic levels. Signals derived from the extracellular milieu are crucial regulators of adaptive immunity. Beyond the traditionally studied cytokines and chemokines, many other extracellular … Read more

Trends Immunol. 2024 Oct 1:S1471-4906(24)00188-1. doi: 10.1016/j.it.2024.08.002. Online ahead of print. ABSTRACT Reciprocal communication between the brain and the immune system is essential for maintaining lifelong brain function. This interaction is mediated, at least in part, by immune cells recruited from both the circulation and niches at the borders of the brain. Here, we describe … Read more

Trends Immunol. 2024 Sep 24:S1471-4906(24)00210-2. doi: 10.1016/j.it.2024.09.002. Online ahead of print. ABSTRACT Circulating immune cells contribute to the pathogenesis of Alzheimer’s disease (AD), but their role is poorly understood. Rosenzweig et al. recently identified a subset of interleukin (IL)-17+ neutrophils that inhibit neuroprotective microglia in female APOE4 carriers. Blockade of IL-17 signaling or APOE4 deletion … Read more

Trends Immunol. 2024 Sep 24:S1471-4906(24)00189-3. doi: 10.1016/j.it.2024.08.003. Online ahead of print. ABSTRACT Neural cells in our central nervous system (CNS) have long been thought to be mere targets of neuroinflammatory events in neurodegenerative diseases such as multiple sclerosis (MS) or Alzheimer’s disease. While glial populations such as microglia and astrocytes emerged as active responders and … Read more

Trends Immunol. 2024 Sep 23:S1471-4906(24)00216-3. doi: 10.1016/j.it.2024.09.008. Online ahead of print. NO ABSTRACT PMID:39317521 | DOI:10.1016/j.it.2024.09.008

Trends Immunol. 2024 Sep 21:S1471-4906(24)00190-X. doi: 10.1016/j.it.2024.08.004. Online ahead of print. ABSTRACT The importance of neuroinflammation in neurodegenerative diseases is becoming increasingly evident, and, in parallel, human induced pluripotent stem cell (hiPSC) models of physiology and pathology are emerging. Here, we review new advancements in the differentiation of hiPSCs into glial, neural, and blood-brain barrier … Read more

Trends Immunol. 2024 Sep 27:S1471-4906(24)00212-6. doi: 10.1016/j.it.2024.09.004. Online ahead of print. ABSTRACT Kloosterman and colleagues studied molecular and cellular changes during radiation therapy and disease recurrence across molecular subtypes of glioblastoma. They uncovered a distinct immune-cancer cell metabolic crosstalk during proneural/oligodendrocyte progenitor cell-like to mesenchymal-like transition, wherein macrophages feed on cholesterol-rich myelin debris to provide … Read more

Trends Immunol. 2024 Sep 27:S1471-4906(24)00194-7. doi: 10.1016/j.it.2024.08.008. Online ahead of print. ABSTRACT The astrocyte, a major glial cell type in the central nervous system (CNS), is widely regarded as a functionally diverse mediator of homeostasis. During development and throughout adulthood, astrocytes have essential roles, such as providing neuron metabolic support, modulating synaptic function, and maintaining … Read more