Frontiers in Immunology
The endogenous Mtv8 locus and the immunoglobulin repertoire
The vast diversity of mammalian adaptive antigen receptors allows for robust and efficient immune responses against a wide number of pathogens. The antigen receptor repertoire is built during the recombination of B and T cell receptor (BCR, TCR) loci a…
Tyrosine phosphatase PTPN11/SHP2 in solid tumors – bull’s eye for targeted therapy?
Encoded by PTPN11, the Src-homology 2 domain-containing phosphatase 2 (SHP2) integrates signals from various membrane-bound receptors such as receptor tyrosine kinases (RTKs), cytokine and integrin receptors and thereby promotes cell survival and proli…
T-cell immunity against senescence: potential role and perspectives
The development of age-associated diseases is related to the accumulation of senescent cells in the body. These are old non-functional cells with impaired metabolism, which are unable to divide. Such cells are also resistant to programmed cell death an…
The critical role of toll-like receptor 4 in bone remodeling of osteoporosis: from inflammation recognition to immunity
Osteoporosis is a common chronic metabolic bone disorder. Recently, increasing numbers of studies have demonstrated that Toll-like receptor 4 (TLR4, a receptor located on the surface of osteoclasts and osteoblasts) plays a pivotal role in the developme…
The NF-κB RelA transcription factor is not required for CD8+ T-cell function in acute viral infection and cancer
CD8+ T cells are critical mediators of pathogen clearance and anti-tumor immunity. Although signaling pathways leading to the activation of NF-κB transcription factors have crucial functions in the regulation of immune responses, the CD8+ T cell-autono…
Integrating PANoptosis insights to enhance breast cancer prognosis and therapeutic decision-making
BackgroundDespite advancements, breast cancer outcomes remain stagnant, highlighting the need for precise biomarkers in precision medicine. Traditional TNM staging is insufficient for identifying patients who will respond well to treatment.MethodsOur s…
Case report: A case of novel homozygous LRBA variant induced by chromosomal segmental uniparental disomy – genetic and clinical insights
ObjectiveThe study aims to report a rare case of a novel homozygous variant in the LRBA gene, originating from uniparental disomy of paternal origin. This case contributes new clinical data to the LRBA gene variant database.MethodsThe study details the…
Causal associations between circulating cytokines and risk of sepsis and related outcomes: a two-sample Mendelian randomization study
IntroductionSepsis represents a critical medical condition that arises due to an imbalanced host reaction to infection. Central to its pathophysiology are cytokines. However, observational investigations that explore the interrelationships between circ…
Association between systemic immune-inflammation index and psoriasis: a population-based study
BackgroundThe systemic immune-inflammation index (SII),as measured by lymphocyte, neutrophil and platelet counts in peripheral blood, is regarded as a favorable indicator of both inflammatory state and immune response. Psoriasis is an immune-mediated d…