Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition
(Immunity 59, 458–476.e1–e13; February 10, 2026)
Immunity
Antibody binding geometry and affinity control inhibitory hFcγRIIB receptor signaling
Understanding FcγR engagement and signaling is central to improving monoclonal antibody therapeutics. Using structural, biophysical, and cellular immunology approaches, Fisher et al. demonstrate how disparate off rates drive the agonism and antagonism …
The transcription factor Eomes drives a stemness program in CD4+ T cells that promotes anti-tumor immunity in response to immunotherapy
The transcription factor Eomes orchestrates the differentiation and maintenance of an exhausted-like Th cell lineage that is transcriptionally and functionally distinct from conventional effector and memory Th subsets. This lineage is amplified by 4-1B…
Stem-like precursors of exhausted Th cells upheld by a Tox-Myb-Eomes transcriptional hierarchy propagate Th cell responses in chronic infection
CD4+ T helper cells are essential for adaptive immunity; however, factors governing their maintenance and function during chronic antigen exposure remain unclear. Wen et al. identify a precursor T cell population, dependent on TOX, EOMES, and MYB, that…
Analysis of West Nile disease convalescents identifies human monoclonal antibodies protective against West Nile and related orthoflaviviruses
No specific prophylaxis or treatment exists for West Nile virus (WNV) or related orthoflavivirus infections. Cervantes Rincón et al. characterize human antibody responses to WNV and identify protective epitopes on the virus envelope protein. A potent m…
Neutrophil regulation of immunotherapy for cancer is controlled by type II interferon
Neutrophils have the capacity to both support and block tumor growth depending on their polarization state. Here, Pei et al. find that IFN-γ produced during immunotherapy induces PD-L1 expression by neutrophils with an aged phenotype that drives therap…
Immunoediting restricts clonal neoantigens in primary, treatment-naive human tumors
Borden et al. examine primary, treatment-naive squamous cell carcinoma (SCC) tumors to determine the impact of immunoediting. Comparison of SCC tumors from immunocompetent and immunosuppressed patients demonstrates immune-mediated sculpting of the tumo…
Astrocyte-microglia crosstalk unlocks Alzheimer’s disease
Altered astrocyte-microglia interactions have been implicated in the pathogenesis of Alzheimer’s disease, but the underpinning mechanisms remain unclear. Zhang and colleagues show that astrocytic PAD2-mediated citrullination of vimentin activates micro…
Fibroblasts hold the key to TLS formation
The presence of tertiary lymphoid structures (TLSs) associates with improved anti-tumor immunity, and as such, understanding why some tumors develop TLSs is of prime interest. In the current issue of Cancer Cell, Kirschstein et al. demonstrate that TGF…
Cholesterol metabolism in immune cells: From mechanisms to therapeutic opportunities
Cholesterol metabolism is an essential component of all immune cells. Xu and colleagues review the immunological functions of cholesterol metabolites and proteins and discuss how distinct cholesterol metabolic programs fulfil the metabolic and signalin…