Vasandan et al. leverage a gene therapy study of X-linked severe combined immunodeficient individuals to longitudinally examine human immune development. They find early emergence of antigen-independent, innate-like memory T cells that are epigenetical…
Bündgen et al. reveal that polyamines in the tumor environment shift Treg cells toward suppression via CK2 signaling. Blocking this pathway reprograms Treg cells to support tissue repair and antitumor immunity. These findings highlight a potential stra…
(Immunity 54, 291–307.e1–e7; February 9, 2021)
While the immune response to Plasmodium falciparum malaria has been studied extensively, the circulating proteome and its cellular origins remain poorly characterized. Lautenbach et al. address this by integrating plasma proteomics and single-cell RNA-…
Macrophages can foster pro- or anti-tumor immune environments. In this issue of Immunity, Clark et al. report that altering the composition of the mitochondrial electron transport chain reprograms macrophages toward a CXCL9hiSPP1lo immunostimulatory ph…
The induction of CD4+Foxp3+ regulatory T cells (pTreg cells) in the intestine is important for preventing allergic and inflammatory disease, but what cells drive their differentiation is less clear. Three manuscripts in Nature, Cell, and Science conclu…
Autonomic imbalance is central to heart failure (HF), but the mechanistic impact of parasympathetic withdrawal has remained unclear. Li, Zhang, Li, et al. demonstrate that targeted optogenetic stimulation of choline acetyltransferase (ChAT)-expressing …
Tumor-infiltrating CD8+ T cells with a tissue-resident memory phenotype have been described in both mice and humans. In this issue of Immunity, Green et al. provide a detailed analysis of the transcriptional and epigenetic regulation of these cells in …
T cells expressing the T cell receptor (TCR) Vγ9Vδ2 chains recognize butyrophilins (BTNs) in the presence of phosphorylated antigens (pAgs). In this issue of Immunity, Zhang et al. and Zhu et al. illustrate the mechanism of TCR-BTN interaction using cr…
Understanding regulation of progenitor exhausted CD8+ T (Tpex) cell differentiation is important for immunotherapies. Humblin et al. report that sustained ICOS costimulation is detrimental to PD-1+CD8+ T cell responses. Limiting ICOS signaling enhances…
