Using a mouse model that selectively lacks TET2 in myeloid cells, Sharma et al. show that myeloid cells and sympathetic neurons form a signaling nexus that controls serotonin production by enterochromaffin cells, which modulates colonic inflammation. F…
The gut microbiome impacts immunity at various levels, including response to immunotherapy. Bachem et al. find that metabolic pathways shared across different microbiota constituents, including SCFA synthesis, modulate stem-like tumor-specific CD127+CD…
David Baltimore, one of modern biology’s most influential scientists, passed away at his home in Woods Hole, Massachusetts, on September 6, 2025 at the age of 87, leaving legions of former trainees and the scientific community to contemplate the signif…
Wang et al. find that cell membrane stress upon viral infection induces expression and stabilization of host sphingomyelin phosphodiesterase acid-like 3B (SMPDL3B), which, in turn, degrades cGAMP to suppress cGAS-STING signaling and promote viral repli…
Artyomov and colleagues provide an overview of studies on age-related changes in the human immune system, from early flow cytometry research to more recent findings using single-cell and advanced cytometry methods. They explore possible sources of disc…
Allergies can persist even in the absence of allergen exposure. Miranda-Waldetario et al. find that IgE-producing plasma cells mature, acquire survival adaptations, and persist for extended periods of time in the spleen and bone marrow, secreting antib…
Bi et al. describe cell-type-specific transcriptional signatures of interferon (IFN) signaling in renal cell carcinoma (RCC) tumors and examine effects on immunotherapy outcomes. They find that myeloid IFNγ signaling, but not tumor IFNγ signaling, pred…
Cancers initially responsive to immune checkpoint inhibitors (ICIs) often relapse, and localized cancers can recur after surgery plus adjuvant ICI therapy. Wu et al. find that relapsing and recurrent melanomas evolve permutations of DNA copy-number var…
Memory CD8+ T cells can undergo TCR-dependent or -independent activation. Here, Lee et al. show that IL-15-induced bystander activation of human memory CD8+ T cells is suppressed by concurrent TCR signaling through NFATc1-AP-1 interactions. Furthermore…
Understanding the mechanisms underlying innate lymphoid cell (ILC) specification may provide insight into ILC functions in immunity and tissue homeostasis. Léger et al. demonstrate that NFIL3 expression in multipotent lymphoid progenitors is necessary …
