The small intestine coordinates nutrient absorption and immune defense, but the epithelial signaling mechanisms bridging these functions are unclear. In this issue of Immunity, Yu et al. reveal a gasdermin-D-driven circuit that links lipid uptake and e…
Dr. Zelig Eshhar, a professor of immunology at the Weizmann Institute of Science and head of immunology research at the Tel Aviv Sourasky Medical Center, passed away on July 3, 2025, at the age of 84. Zelig was best known as the pioneer of chimeric ant…
Clinical and therapeutic innovation relies on our understanding of the human immune system. Here, investigators discuss current and developing methodologies to study human immunity, and the importance of thoughtful experimental design and sample collec…
Specialized macrophages are known to persist within tissue niches, but the molecular mechanisms guiding their sustained functional adaptation remain unclear. Kolter and Döring et al. show that local interactions between sensory nerves and macrophages a…
Microglia-mediated neuroinflammation drives Alzheimer’s disease (AD) pathogenesis, yet the underlying mechanism is poorly understood. Song et al. demonstrate that toxic amyloid-β induces oxidation and fragmentation of mitochondrial DNA in microglia, fa…
Pregnancy-induced microchimerism is linked with both inflammatory disorders and immune tolerance phenotypes. Peng et al. develop a platform for lineage-specific microchimeric cell depletion and show that tolerance to non-inherited maternal antigens is …
Transcription factors are known to guide dendritic cell identity, but how they cooperate to drive lineage diversification remains unclear. Henriques-Oliveira, Altman, Kurochkin, et al. identify two transcription factor triads that remodel chromatin and…
The transporter associated with antigen processing (TAP) delivers peptide antigens from the cytoplasm into the endoplasmic reticulum for loading onto MHC-I molecules. Lee et al. generate cryo-electron microscopy structures of the human TAP heterodimer …
Inflammatory bowel disease is a multifactorial disease driven by combinations of susceptibility factors. Kaya et al. demonstrate how XBP1 deficiency impairs MUC2-mediated mucus barrier formation. Diminished mucus formation synergizes with epithelial ce…
(Immunity 57, 1–13.e1–e8; September 10, 2024)
