Metabolic reprogramming is a hallmark of cancer. Liu et al. demonstrate that in hepatocellular carcinoma, inflammatory macrophage-driven efflux of N1-acetylspermidine operates in a charge-dependent manner to polarize CCL1+ macrophages, which in turn re…
The pathways regulating Th1 cell contraction are not well understood. Rahman et al. demonstrate that complement receptor C5aR2 controls T cell-intrinsic prostanoid metabolism as an integral component of Th1 cell contraction. Faulty C5aR2-prostanoid rew…
Polyclonal Mycobacterium tuberculosis-specific antibody-mediated effector functions correlate with improved infection in humans; however, the precise antibody specificities and functions that contribute to this control remain undefined. Grace et al. em…
Sensory innervation impacts several lung diseases, but whether it influences pulmonary fibrosis (PF) is unclear. Hiroki et al. report that depletion of TRPV1+ nociceptors leads to worsening of inflammation-induced PF. Mechanistically, nociceptor deplet…
(Immunity 58, 1236–1253.e1–e8; May 13, 2025)
(Immunity 56, 2736–2754.e1–e8; December 12, 2023)
Green et al. establish a multiomic single-cell atlas of antigen-specific CD8+ T cell states across infection and cancer, revealing enhancer-driven gene regulatory networks governing CD8+ T cell differentiation and tissue adaptation. They demonstrate th…
Why microglia stop reducing amyloid deposits from Alzheimer’s disease (AD) brains is unknown. Prakash, Manchanda, et al. show that microglia increase their lipid droplets and lose their phagocytic capacity with increasing Aβ exposure or proximity to pl…
Blidner et al. identify a glycosylation-dependent, galectin-driven circuit as a common mechanism that simultaneously induces immunosuppressive and pro-angiogenic functions in myeloid-derived suppressor cells, revealing therapeutic opportunities to targ…
Maternal immune activation during pregnancy is associated with neurodevelopmental disorders in offspring, yet how maternal-fetal interface perturbations influence prenatal fetal myeloid cells and induce neurodevelopmental disorders remain unclear. Bian…
