ATG16L1T300A is associated with Crohn’s disease and causes immune dysfunction in mouse models, yet a plurality of humans are heterozygous carriers. Yao, Rudensky, et al. find that the ATG16L1 disease variant alters protein-protein interaction. Conseque…
The functional role of TMEM119, a homeostatic microglial marker, has not been fully elucidated under Alzheimer’s disease (AD) pathological conditions. Liu et al. demonstrate that microglial TMEM119 actively participates in the dynamic clearance of amyl…
T helper (Th) 2 cells and group 2 innate lymphoid cells (ILC2s) express similar effector molecules in response to distinct signals—TCR engagement and interleukin-33, respectively. Guichard et al. find that NF-κB is essential for type 2 cytokine product…
The critical immunoregulatory function of the lung nerve- and airway-associated macrophages (NAMs) is increasingly becoming evident. In this issue of Immunity, Yeung et al. report that NAMs’ response to type I interferon limits SARS-CoV-2 spread, infla…
Long-term consumption of diets high in fats has detrimental impacts on the immune system, but the window necessary for initiating these effects is unclear. In this issue of Immunity, Xiong et al. demonstrate that even short-term exposure to saturated f…
Liver regeneration is a remarkable and unique biological process, orchestrated by an intricate cellular crosstalk of (non-)parenchymal, immune, and nerve cells. In this issue of Immunity, Modares et al. uncover the pivotal role of choline acetyltransfe…
Pancreatic cancer has traditionally been considered refractory to immunotherapy. In a follow-up to the first clinical trial of personalized mRNA vaccines against this deadly cancer, published in Nature, Sethna et al. report compelling evidence of long-…
Sickle cell disease (SCD) inhibits CD8+ T cell function in the tumor microenvironment, potentially affecting cancer immunotherapy. Zhao, Hu, Deng, et al. reveal that SCD alters the 3D genome architecture of CD8+ T cells, triggering ferroptosis and impa…
Rapid viral evolution challenges the efficacy of vaccines and other medical interventions. Our ability to evaluate interventions is currently limited to assessments against past or circulating variants. Youssef et al. developed EVE-Vax, a computational…
Initial specificity is thought to be required for somatic hypermutation (SHM)-driven antibody evolution. Zuo, Gautam, et al. demonstrate that non-cognate B cells can enter germinal centers, undergo SHM, and acquire new antigen specificities, highlighti…
