The immune landscape of human and murine thrombosis remains unclear. Pekayvaz et al. map the immune landscape of thrombosis and describe prominent thrombolytic functions of immune cells, a pattern that they term immunothrombolysis: neutrophils recruite…
Glioblastoma is an aggressive subtype of glioma that responds poorly to immune checkpoint blockade (ICB). Galvez-Cancino et al. demonstrate that Treg cell depletion using a non-IL-2 blocking antibody—antiCD25NIB—activates CD8+ T cells and recruits FcγR…
Xiong et al. report that short-term, high-fat diet exposure rapidly alters the gut microbial and immune environment, disrupting tissue homeostasis. IL-22 production by group 3 innate lymphoid cells (ILC3s) is impaired, compromising gut barrier integrit…
Shen et al. show that A. faecalis induces intestinal Th17 cells under physiological conditions. A. faecalis proteins endocytosed by CD4+ T cells via CDC42 or OMVs prevent Trim21 self-ubiquitination degradation. Then, Trim21 enhances JunB-induced Ahr tr…
Specialized T cells can support tissue remodeling, but how T cells contribute to mammary gland remodeling during pregnancy is not fully understood. In a recent Cell issue, Corral et al. demonstrate that self-sensing T cells migrate to the mammary gland…
cGAS-cGAMP-STING and OAS-2-5A-RNase L are evolutionarily convergent innate immune pathways. cGAMP acts as an immunotransmitter; what about 2-5A? In this issue of Immunity, Huai et al. map the transfer of 2-5A between cells, establishing it as a bona fi…
Mitochondrial dysfunction is a feature of cellular senescence. Lai et al. find that senescent tumor cells release mitochondrial (mt)DNA into the extracellular space, where it is taken up by PMN-MDSCs. Internalized mtDNA activates the cGAS-STING-NF-κB p…
While neuroinflammatory responses driven by microglia and astrocytes have been extensively linked to neurodegenerative disease progression in amyotrophic lateral sclerosis (ALS), the specific pathways that coordinate glial cell-dependent neuroinflammat…
The combination of antiangiogenic and immune checkpoint inhibitor (ICI) treatment is active in solid tumors, but the mechanism of response remains unclear. In this issue of Immunity, Benmebarek et al. show that anti-vascular endothelial growth factor e…
Long-lived memory B cells developing from germinal centers (GCs) are important contributors to protective immunity. In this issue of Immunity, Luo et al. report that during primary responses, T cell-derived interleukin-9 potentiates differentiation of …
