Microglia are heterogeneous cells that underlie numerous roles in brain development and neurodegenerative disease. Barclay et al. generate Clec7a-CreERT2 mice to profile, track, and deplete two microglial states, proliferative-region-associated microgl…
Low persistence and reduced activity of NK cells limit anti-tumor immunity. Sun, Nagahama, et al. find that NK cell-specific deficiency of the endonuclease Regnase-1 promotes NK cell persistence in the tumor microenvironment via continuous expression o…
Infiltrating immune cells are important contributors to tissue fibrosis. Here, Liang et al. reveal that intestinal ILC3s migrate to the kidney via CXCR6/CXCL16 during renal fibrosis. Within the kidney, immigrated ILC3s express PD-1, which regulates IL-…
Tumor cells frequently hijack RIPK1’s scaffolding function to resist cell death and avoid immune detection. Mannion et al. describe the development of a RIPK1-selective PROTAC degrader that boosts the immunostimulatory and antitumor activity of radioth…
Malaria vaccine development targeting blood-stage infections requires a correlate of protection. Nkumama et al. leverage a controlled human malaria infection model to study mechanisms of acquired immunity. They show that the breadth of IgG Fc-mediated …
Steady-state antigen recognition triggers tolerant CD8+ T cell states that restrain autoimmunity and limit anti-cancer immunity. The relationship between tolerant states and other differentiation states remains unclear. Van Der Byl et al. demonstrate t…
In contrast to other immune cell lineages, little is known about how eosinophils develop, expand, and mature in health and disease. Using single-cell RNA sequencing, high-dimension flow cytometric screening, and IL-5Rα reporter mice, Jorssen, Van Hulst…
Obesity induces ILC2 dysfunction in adipose tissue and insulin resistance by undetermined mechanisms. Here, Sun et al. show that liver kinase B1 (LKB1) signaling protects ILC2s from mitophagy by suppressing PD-1 expression. Moreover, PD-1 blockade rest…
How immune and epithelial cells simultaneously fuel their dysfunction in chronic skin diseases is unclear. Subudhi and Konieczny et al. find that IL-17-induced epithelial HIF1α activates glycolysis, which potentiates the γδ T17 response via lactate. Th…
Cellular and molecular mechanisms leading to SLE are unclear. Li et al. show that SLE CD4+ T cells downregulate CBLs and ablation of CBLs in mouse T cells causes hyper Tfh cell responses and SLE. CBLs restrain Tfh cell responses by ubiquitinating ICOS,…
