How innate signaling mechanisms are fine-tuned in response to infection remains to be fully elucidated. Here, Harioudh et al. reveal a noncanonical role for the interferon-stimulated gene OAS1. OAS1 binds to Irf1 mRNA, localizing it to endomembranes fo…
Immunometabolites are important in autoinflammation and autoimmune disorders but need to be further identified. Xu et al. reveal that spermine acts as an endogenous JAK1 inhibitor by directly binding JAK1 to restrain type I/II cytokine responses. In vi…
Immune cell function is shaped by the cell metabolic activity, but how metabolism programs and stabilizes immune states within tissues is not well understood. Mertens et al. reveal that a metabolic switch triggered by IL-18 activation of SLC12A3 (NCC) …
An association between autoimmunity and malaria was first reported over 50 years ago, but the mechanisms remain unclear. Hagadorn et al. found that people in Mali with high levels of autoantibodies are protected from malaria and that autoantibodies inh…
Regulatory T (Treg) cells found in peripheral tissues were considered tissue restricted. Here, Burton et al. demonstrate that tissue Treg cells share a common phenotype and T cell receptor (TCR) repertoire, which confers multi-tissue migration. Thus, t…
Memory B cells (MBCs) underlie long-lived humoral immunity and are key to the efficacy of prime-boost vaccines. Wang et al. find that MBCs differ in their recall ability and that expression of the transcription regulator ZFP318, which regulates express…
Dietary restriction is associated with improved elimination of cancer cells, and fasting regimens are being tested in clinical settings in combination with cancer therapies. Using a cyclic fasting diet (CFD), Delconte et al. show that natural killer (N…
Aicardi-Goutières syndrome is an autoinflammatory brain disease associated with increased interferon-α production, but the primary source and mediators of neurotoxicity are poorly described. Viengkhou et al. show that neurotoxic interferon-α originates…
Infants are highly vulnerable to RSV infection. However, the contribution of the evolving RSV-specific humoral immune response to RSV immunity remains incompletely understood. Nziza et al. profiled pediatric humoral immunity to RSV fusion and attachmen…
Allogeneic T cell expansion is the primary determinant of graft-versus-host disease (GVHD), and current dogma dictates that this is driven by histocompatibility antigen disparities between donor and recipient. Yeh et al. found that a subset of donor CD…
