Mast cell maturation dictates their secreted factors and functions. This process, however, remains unresolved. Taketomi et al. present lipid mediators as a central hub of mast cell maturation. They further detail a highly coordinated mast cell-fibrobla…
We suggest that the U, L, W, and J age-dependent patterns of death from infection result from the interplay between (1) genotypes affecting immunity to primary infection, related genotypes, or their phenocopies later in life and (2) the occurrence and …
The association of tertiary lymphoid structures (TLSs) with survival and immunotherapy response brought B cells to center stage. In a pan-cancer B cells atlas in Science, Ma et al. show that germinal center reaction generating anti-tumor antibody-secre…
Skin inflammation is potentiated by coordinated epithelial and immune cell metabolism. In this issue of Immunity, Subudhi and Konieczny et al. delineate how HIF1α regulates epithelial cell glycolysis during psoriasis. In turn, lactate is a byproduct th…
Autoreactive lymphocytes that infiltrate the pancreatic islet environment and target β cells are primary drivers of type 1 diabetes. In this issue of Immunity, Srivastava et al. examine the role of the islet microenvironment in autoimmunity and find th…
Antibodies modulate ongoing and future B cell responses. Cyster and Wilson review the various mechanisms whereby antibody feedback shapes B cell responses and present a framework for conceptualizing the ways antigen-specific antibody may influence immu…
(Immunity 57, 1225–1242.e1–e6; June 11, 2024)
RIPK1 is known as a driver of cell death and inflammation. In this issue of Immunity, Imai et al. and Mannion et al. find that these same processes are also induced by RIPK1 inactivation and highlight the therapeutic potential of RIPK1 elimination.
Interleukin-1 (IL-1) family cytokines are key immunological regulators that achieve their signaling prowess after post-translational proteolytic processing. In this issue of Immunity, Dong et al. reveal the structural consequences of this process on pr…
The nasal mucosa is a key barrier for respiratory infections, but the cellular responses therein are poorly understood. Kazer et al. generate a longitudinal tissue-scale single-cell nasal atlas during IAV infection and rechallenge, identifying unique e…
