Trends Immunol. 2024 Sep 25:S1471-4906(24)00214-X. doi: 10.1016/j.it.2024.09.006. Online ahead of print.
ABSTRACT
Extrahepatic, cell-autonomous, and/or intracellularly active complement components are increasingly recognized as key orchestrators of cell physiological processes. A recent study by Scott-Hewitt et al. demonstrates that microglia-derived C1q unexpectedly associates with the ribosomes of neurons in the aging murine brain, where it impacts protein translation and impairs the extinction of conditioned fear responses.
PMID:39327206 | DOI:10.1016/j.it.2024.09.006