Paradigm shift in macrophage polarization in osteoarthritis: from M1/M2 imbalance to macrophage state reprogramming in the ageing immune microenvironment
Osteoarthritis (OA) is one of the most common degenerative joint diseases, and its initiation and progression are closely associated with the inflammatory microenvironment within the joint. As key effector cells of innate immunity in the joint, macroph…