Bronchiectasis is a complex and heterogeneous disease, and our current understanding of its pathophysiological mechanisms remains in its infancy. Currently, few specifically approved treatments for non-cystic fibrosis bronchiectasis are applied globall…
Mature B-cell neoplasms constitute a biologically and clinically heterogeneous group of hematologic malignancies, defined by the clonal proliferation and accumulation of monotypic mature B lymphocytes, which may involve the peripheral blood, bone marro…
Sepsis-induced acute lung injury (ALI) remains a leading cause of mortality in critically ill patients and is characterized by dysregulated inflammation, immune imbalance, and alveolar–capillary barrier dysfunction. Emerging evidence suggests that circ…
BackgroundInitially recognized for its role in hematopoiesis, Interleukin-11 (IL-11) is now understood to possess a wide spectrum of biological activities. It is involved in critical physiological processes, including immune cell differentiation, infla…
In innate immunity, Piezo1 influences macrophage polarization, neutrophil migration, inflammation and repair. In adaptive immunity, it modulates T cell mechanosensation, immune synapse formation and B cell antigen presentation. Expressed in endometrium…
Silicosis is an irreversible fibrotic interstitial lung disease triggered by chronic exposure to respirable crystalline silica (RCS). Currently, effective therapeutic interventions for this disease remain lacking, as existing clinical approaches are li…
Fibrinogen-like protein 1 (FGL1) has been recently identified as an emerging novel checkpoint ligand of lymphocyte activation gene-3 (LAG-3) with important immunoregulatory functions. In addition to LAG-3, FGL1 also interacts with bone morphogenetic pr…
Alzheimer’s disease (AD) is increasingly recognized as a disorder of innate immune dysregulation within the central nervous system. The triggering receptor expressed on myeloid cells 2 (TREM2), a microglial immunoreceptor, has emerged as a pivotal gene…
For decades, sex disparities have been acknowledged to influence immune regulation in health and disease throughout the life span, and contribute to variations in epidemiology, pathophysiology, manifestation, progression, and therapeutic response in mu…
Nasopharyngeal carcinoma (NPC) is strongly associated with Epstein-Barr virus (EBV) infection, but EBV alone is insufficient for tumorigenesis. Recent evidence suggests that the nasopharyngeal microbiome plays a critical, yet underexplored, role in NPC…
