Cigarette smoke exposure triggers dendritic cell-derived exosome-mediated Th17 and Treg polarization through an autophagy- and necroptosis-associated SIRT1-dependent mechanism in vitro
IntroductionBoth Th17/Treg cell imbalance and dendritic cells (DCs) play critical roles in chronic obstructive pulmonary disease pathogenesis from cigarette smoke. Previous studies have shown that DC-derived exosomes (DCexos) can polarize CD4+ T cells …