Delayed B-cell reconstitution in the bone marrow precedes the development of chronic graft-versus-host disease following pediatric hematopoietic stem cell transplantation
IntroductionAllogeneic hematopoietic stem cell transplantation (HSCT) in children remains challenged by chronic graft-versus-host-disease (cGvHD), significantly affecting morbidity and survival. While aberrant peripheral B-cell reconstitution has been …