Novel assays to assess the prevalence and neutralizing potential of anti-IdeS antibodies in healthy humans
BackgroundThe IgG-degrading enzyme IdeS (imlifidase) is a cysteine protease produced by Streptococcus pyogenes. It specifically hydrolyzes human IgG, cleaving the molecule to separate the F(ab’)2 fragment from the Fc region, thereby promoting IgG catab…