The exosomal miR-26b-3p derived from Crohn’s disease-associated mesenteric adipose tissue induces M1 macrophage polarization and exacerbates ileocolonic anastomosis inflammation via the p38-MAPK signaling pathway
PurposeCrohn’s Disease (CD) is a chronic inflammatory condition characterized by intestinal inflammation, especially in the progression of postoperative anastomotic recurrence. Recent evidence implicates mesenteric adipose tissue (MAT) in CD pathogenes…