Effect of the autoimmune-associated genetic variant PTPN22 R620W on neutrophil activation and function in patients with insulin-dependent diabetes mellitus
IntroductionRecent evidence highlights neutrophils’ role in initiating/sustaining aberrant immune responses in type 1 diabetes (T1D). The PTPN22 C1858T variant, a risk factor for several autoimmune conditions including T1D, affects T/B-cell receptor si…