The CXCL9/SPP1 polarity axis in tumor-associated macrophages: immunoregulatory and prognostic significance in non-small cell lung cancer
This study addresses the limitations of the traditional M1/M2 binary classification for tumor-associated macrophages (TAMs) in non-small cell lung cancer (NSCLC) by introducing a NSCLC-specific functional framework based on the CXCL9/SPP1 (CS) expressi…