Hui Chen – InmunoES

Integrated single-cell and bulk tissue analyses reveal distinct macrophage subtypes and a candidate prognostic signature in colorectal cancer: implications for tumor immune characterization

18 de September de 2026 by Hui Chen

IntroductionColorectal cancer (CRC) represents a major global health burden, marked by high morbidity and mortality rates that place a considerable strain on healthcare systems.MethodsThis study leveraged integrated bioinformatic analyses, single-cell …

Clinical application of HMGB1-TLR4 signaling pathway-mediated neuroinflammatory markers in infantile epileptic spasms syndrome

1 de May de 2026 by Hui Chen

BackgroundInfantile epileptic spasms syndrome (IESS) is a severe age-specific epileptic encephalopathy with unclear pathogenesis, and neuroinflammation is involved in its progression. The HMGB1-TLR4 signaling pathway, a key neuroinflammatory mediator i…

Association of TCRαβ+ double-negative T cells with the response to glucocorticoids in pediatric patients with immune thrombocytopenia

30 de July de 2025 by Hui Chen

ObjectivesPediatric primary immune thrombocytopenia (ITP) is an acquired autoimmune disease that can be partially restored by glucocorticoids. TCRαβ+CD4−CD8− double negative T cells (TCRαβ+DNT) has been linked to the pathophysiology of ITP; however, th…