J Immunol. 2025 Mar 12:vkae050. doi: 10.1093/jimmun/vkae050. Online ahead of print. ABSTRACT Porphyromonas gingivalis (Pg) is a prevalent pathogen that promotes human periodontal disease (PD) and exacerbates systemic comorbidities such as atherosclerosis, rheumatoid arthritis, and Alzheimer’s disease. Pg produces nonphosphorylated tetra-acylated lipid A (NPLA) in its outer membrane (OM) that evades host Toll-like receptor 4 … Read more

J Immunol. 2025 Mar 24:vkaf002. doi: 10.1093/jimmun/vkaf002. Online ahead of print. ABSTRACT Currently, anti-inflammatory drugs fail to reduce pulmonary fibrosis and tissue remodeling in the clinic. Thus, there is an unmet need to develop novel antifibrotic drugs capable of reversing disease. Our lab has identified two novel mediators of pulmonary fibrosis belonging to the tumor … Read more

J Immunol. 2025 Mar 24:vkaf003. doi: 10.1093/jimmun/vkaf003. Online ahead of print. ABSTRACT Natural killer (NK) cell activation is regulated by killer cell immunoglobulin-like receptors (KIRs) that recognize human leukocyte antigen (HLA) class I molecules. While polymorphism in HLA can directly impact these interactions, the extent to which the HLA-associated peptide repertoire modulates NK cell function … Read more

J Immunol. 2025 Mar 22:vkaf015. doi: 10.1093/jimmun/vkaf015. Online ahead of print. ABSTRACT Polyreactivity is the ability of antibodies to bind to various unrelated antigens with low affinities and is a frequent feature of HIV-1 broadly neutralizing antibodies (bNAbs). Besides naturally occurring polyreactivity, human immune repertoires contain antibodies that can acquire polyreactivity de novo, by their … Read more

J Immunol. 2025 Mar 22:vkaf009. doi: 10.1093/jimmun/vkaf009. Online ahead of print. ABSTRACT Cytotoxic T cell (CTL) exhaustion is driven by chronic T cell receptor (TCR) stimulation, leading to a dysfunctional state of cells. Exhausted CTLs exhibit diminished effector function against chronic infections and cancers. Therefore, reducing CTL exhaustion may re-establish effective adaptive immune responses. One … Read more

J Immunol. 2025 Mar 22:vkaf020. doi: 10.1093/jimmun/vkaf020. Online ahead of print. ABSTRACT Galectins are expressed by different immune and nonimmune cells with diverse immunomodulatory properties. However, their roles in erythropoiesis remain unknown. We investigated the expression of galectin genes in splenic CD71+ erythroid cells (CECs) from neonatal BALB/c mice at various developmental stages using bulk … Read more

J Immunol. 2025 Mar 22:vkaf019. doi: 10.1093/jimmun/vkaf019. Online ahead of print. ABSTRACT Major depression disorder is a common illness that severely limits psychosocial functioning, affects outcomes of other diseases, and diminishes the quality of life. High-salt diet (HSD) has long been closely associated with the occurrence and development of depression, but whether or how HSD … Read more

J Immunol. 2025 Mar 22:vkaf023. doi: 10.1093/jimmun/vkaf023. Online ahead of print. ABSTRACT Acute graft-versus-host disease (GVHD) is a donor T cell driven complication and the leading cause of non-relapse mortality in patients receiving an allogeneic hematopoietic cell transplantation (allo-HCT). Allogeneic donor T cells eradicate residual leukemia and prevent relapse via the graft-versus-leukemia (GVL) effect and … Read more