inmunoadmin Cancer Immunol Res. 2025 Mar 11. doi: 10.1158/2326-6066.CIR-24-0804. Online ahead of print. ABSTRACT mRNA vaccines are recognized as potent tools for immunization against viral diseases and cancer. However, the lack of a vaccine adjuvant limits the efficacy of these treatments. Here, we used cGAS mRNA, which encodes the DNA innate immune sensor, complexed with lipid … Read more
Cancer Immunol Res. 2025 Mar 11. doi: 10.1158/2326-6066.CIR-24-0263. Online ahead of print. ABSTRACT Cytotoxic chemotherapy that kills cancer cells can also elicit anti-tumor immune responses. Therefore, understanding the immunogenic context of cytotoxic chemotherapy can improve combination immunotherapies. In this study, we sought to improve our understanding about dendritic cell (DC) dynamics in cytotoxic chemotherapy-treated tumor … Read more
Trends Immunol. 2025 Mar 10:S1471-4906(25)00024-9. doi: 10.1016/j.it.2025.01.006. Online ahead of print. ABSTRACT Arthritis is associated with varying degrees of intestinal inflammation and microbiota dysbiosis, leading to the ‘gut-joint axis hypothesis’ in which intestinal and joint inflammation are suggested to be interconnected through immune-microbiota interactions. While clinical observations support this, causality remains uncertain. Rodent models have … Read more
J Clin Immunol. 2025 Mar 11;45(1):80. doi: 10.1007/s10875-025-01870-6. NO ABSTRACT PMID:40067421 | DOI:10.1007/s10875-025-01870-6
Our study reveals that high-dose UVB exposure stimulates Langerhans cells to release chemokines that recruit neutrophils and induce TNF-α-mediated apoptosis in DNA-damaged keratinocytes. Without Langerhans cells, fewer neutrophils are recruited, leading to an accumulation of DNA-damaged cells and a higher risk of skin cancer due to increased mutations and potential cell transformation. Abstract Ultraviolet (UV) … Read more
Low-dose IL-2 balances Tfh, Tph, and Treg cells in myasthenia gravis (MG), by increasing Treg cells and reducing Tfh and Tph cell populations in patients. The results provide in vitro evidence for the use of IL-2 as a potential therapeutic in MG. Abstract Follicular helper (Tfh), peripheral helper (Tph), and regulatory (Treg) T cells are … Read more
A review of lipid nanoparticle development and application for engineering T cells, NK cells, macrophages, dendritic cells, and stem cells for immunotherapies. Abstract Lipid nanoparticles (LNPs) have emerged as the preeminent nonviral drug delivery vehicles for nucleic acid therapeutics, as exemplified by their usage in the mRNA COVID-19 vaccines. As a safe and highly modular … Read more
After a hesitant start, the number of available therapeutics that target the human complement system has surged from one to a dozen drugs in less than 20 years. Meanwhile, the clinical arsenal encompasses treatment modalities directed to several targets for the therapy of a steadily growing spectrum of complement-related disorders. Abstract Therapeutic interventions in the … Read more
(Top). Representative protumorigenic GPCRs can regulate cancer at multiple levels, including immune cell recruitment to TME, angiogenesis, and tumor biology. (Bottom). Multiple and parallel targeting of selected protumorigenic GPCRs might overcome receptor redundancy and impede tumor growth on various fronts, thus increasing the therapeutic potential of GPCR-targeted therapies. Abstract G protein-coupled receptors (GPCRs) are vital … Read more
Older and obese individuals are at greater risk of developing severe COVID-19. In this paper, we identified that this may be related to decreased levels of testosterone and estradiol, by showing that these sex hormones reduce the excessive production of proinflammatory cytokines induced by anti-SARS-CoV-2 IgG antibodies. Abstract COVID-19, the disease caused by SARS-CoV-2, particularly … Read more
