After a hesitant start, the number of available therapeutics that target the human complement system has surged from one to a dozen drugs in less than 20 years. Meanwhile, the clinical arsenal encompasses treatment modalities directed to several targets for the therapy of a steadily growing spectrum of complement-related disorders. Abstract Therapeutic interventions in the … Read more

(Top). Representative protumorigenic GPCRs can regulate cancer at multiple levels, including immune cell recruitment to TME, angiogenesis, and tumor biology. (Bottom). Multiple and parallel targeting of selected protumorigenic GPCRs might overcome receptor redundancy and impede tumor growth on various fronts, thus increasing the therapeutic potential of GPCR-targeted therapies. Abstract G protein-coupled receptors (GPCRs) are vital … Read more

Older and obese individuals are at greater risk of developing severe COVID-19. In this paper, we identified that this may be related to decreased levels of testosterone and estradiol, by showing that these sex hormones reduce the excessive production of proinflammatory cytokines induced by anti-SARS-CoV-2 IgG antibodies. Abstract COVID-19, the disease caused by SARS-CoV-2, particularly … Read more

ThymoSpheres provide an innovative, user-friendly in vitro model for generating mature, predominantly CD8 single positive T cells. These cells resemble human polyclonal αβ unconventional T cells in transcriptome and TCR repertoire characteristics, making this model valuable for studying the development of this specific T-cell lineage. Abstract In vitro cultures remain crucial for studying the fundamental … Read more