inmunoadmin

Age and Latent Cytomegalovirus Infection Do Not Affect the Magnitude of De Novo SARS‐CoV‐2‐Specific CD8+ T Cell Responses. [[{“value”:”Jet van den Dijssel, Veronique A. L. Konijn, Mariël C Duurland, Rivka de Jongh, Lianne Koets, Barbera Veldhuisen, Hilde Raaphorst, Annelies W. Turksma, Julian J. Freen‐van Heeren, Maurice Steenhuis, Theo Rispens, C Ellen van der Schoot, S. Marieke van Ham, Rene A. W. van Lier, Klaas P. J. M. van Gisbergen, Anja ten Brinke, Carolien E. van de Sandt”}]]

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Immunosenescence and cytomegalovirus infection are suggested to impair protective immunity against novel pathogens. Despite reduced total CD8+ Tnaïve cells in older CMV– and CMV+ individuals, our study found a broad and robust memory SARS-CoV-2-specific CD8+ T cell response in both younger and older convalescent COVID-19 donors regardless of CMV status. ABSTRACT Immunosenescence, age-related immune dysregulation, … Read more

A Critical Oversight in Immunology Research: The Prevalence of Complement Deficiencies in Mouse Models. África González‐Fernández

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Several mouse strains have a genetic deficiency in the fifth component of complement (C5). This defect affects research outcomes in areas such as allergies, autoimmunity, cancer, infectious diseases, and inflammation. ABSTRACT The complement system is a crucial component of the innate immune response, playing a vital role in defending the body against pathogens and maintaining … Read more

Vaginal Prevotella timonensis Bacteria Enhance HIV‐1 Uptake and Differentially Affect Transmission by Distinct Primary Dendritic Cell Subsets. [[{“value”:”Marleen Y. van Smoorenburg, Ester B. M. Remmerswaal, Celia Segui‐Perez, John L. van Hamme, Karin Strijbis, Teunis B. H. Geijtenbeek”}]]

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The bacterium Prevotella timonensis found in vaginal dysbiosis enhances the uptake of HIV-1 by primary dendritic cells. Virus is internalised into tetraspanin-rich compartments, which leads to efficient HIV-1 transmission to target cells. These results provide insight into how microbiota directly affect HIV-1 uptake thereby altering HIV-1 susceptibility. Created in BioRender. Geijtenbeek, T. (2025) https://BioRender.com/i89c292. ABSTRACT … Read more

Maximizing Insights, Minimizing Animal Testing: A Framework for Validating Multiparametric Single‐Cell Cytokine Analysis Panels. [[{“value”:”Johann Aleith, Wendy Bergmann‐Ewert, Brigitte Müller‐Hilke”}]]

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Multicolor spectral flow cytometry panels for cytokine expression analysis were optimized and validated without animal testing. Stimulated co-cultures of helper T cells, splenocytes, and fibroblast-like synoviocytes provided a complex cellular environment suitable for validating intracellular cytokine staining. This approach offers a more ethical alternative to commonly used animal disease models. ABSTRACT Intracellular cytokine labeling combined … Read more

Two New Kindreds with Complete Factor D Deficiency. [[{“value”:”Mathilde Puel, Kenza Rwayane, Paula Vieira Martins, Marwa Chbihi, Frédéric Rieux‐Laucat, Jérémie Rosain, Eric Jeziorski, Bertrand Boisson, Jean‐Laurent Casanova, Véronique Frémeaux‐Bacchi, Carine El Sissy”}]]

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The complement system plays a crucial role in immune defense, and factor D deficiency is a rare immunodeficiency associated with life-threatening bacterial infections. We report two new cases of complete factor D deficiency, including the first described in a Down syndrome patient, highlighting the need to investigate complement deficiencies in patients with secondary immunosuppression. Given … Read more

Genetic evidence for the suppressive role of zebrafish vhl targeting mavs in antiviral innate immunity during RNA virus infection

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J Immunol. 2025 Jan 1;214(1):167-179. doi: 10.1093/jimmun/vkae017. ABSTRACT The von Hippel-Lindau (VHL) tumor suppressor gene VHL is a classic tumor suppressor that has been identified in family members with clear cell renal cell carcinomas, central nervous system and retinal hemangioblastomas, phaeochromocytomas, and pancreatic neuroendocrine tumors. The well-defined function of VHL is to mediate proteasomal degradation … Read more

Lipin-1 restrains macrophage lipid synthesis to promote inflammation resolution

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J Immunol. 2025 Jan 1;214(1):85-103. doi: 10.1093/jimmun/vkae010. ABSTRACT Macrophages are critical to maintaining and restoring tissue homeostasis during inflammation. The lipid metabolic state of macrophages influences their function and polarization, which is crucial to the resolution of inflammation. The contribution of lipid synthesis to proinflammatory macrophage responses is well understood. However, how lipid synthesis regulates … Read more

Plasmacytoid dendritic cell sensing of African swine fever virus-infected macrophages results in STING-dependent robust interferon-α production

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J Immunol. 2025 Jan 1;214(1):130-140. doi: 10.1093/jimmun/vkae008. ABSTRACT While several African swine fever virus (ASFV)-encoded proteins potently interfere with the cGAS-STING (cyclic GMP-AMP synthetase-stimulator of interferon genes) pathway at different levels to suppress interferon (IFN) type I production in infected macrophages, systemic IFN-α is induced during the early stages of AFSV infection in pigs. The … Read more

Precise motif and cross-presentation of coronavirus peptides by feline MHC class I: implications for the mild infection of SARS-CoV-2

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J Immunol. 2025 Jan 1;214(1):115-129. doi: 10.1093/jimmun/vkae006. ABSTRACT As one of the earliest identified susceptible animals for the SARS-CoV-2, cats are also the vulnerable hosts for feline coronaviruses, ie feline enteric coronavirus (FECV). Here, to understand the cross-presentation of coronavirus-derived peptides by cat major histocompatibility complex molecule feline leucocyte antigen (FLA) class I, unpredictable natural … Read more

Suppression of NF-κB and downstream XBP1 by DcR3 contributes to a decrease in antibody secretion

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J Immunol. 2025 Jan 1;214(1):72-84. doi: 10.1093/jimmun/vkae005. ABSTRACT Decoy receptor 3 (DcR3), a soluble receptor in the tumor necrosis factor receptor superfamily, regulates the functions of monocytes, macrophages, dendritic cells, and T cells. Previous studies have demonstrated that DcR3 suppresses B cell proliferation in vitro and ameliorates autoimmune diseases in animal models; however, whether and … Read more

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