inmunoadmin

Anti-TNF therapy in the treatment of systemic autoinflammatory diseases: the responses of innate immune cells​Shuyi Wang on 14 de March de 2025 at 10:00

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J Leukoc Biol. 2025 Mar 14:qiaf026. doi: 10.1093/jleuko/qiaf026. Online ahead of print. ABSTRACT Systemic autoinflammatory diseases (SAIDs) are rare conditions resulting from innate immune system dysregulation, culminating in repetitive bouts of systemic inflammation without the presence of external or self-antigens. Most SAIDs are associated with mutations in genes affecting the innate immune response. Tumor necrosis … Read more

Utility of the NLR and the ratio of NLR after and before adverse events for differential diagnosis of irAEs and bacterial infections in cancer patients treated with PD-(L)1 inhibitors​Lu Han on 14 de March de 2025 at 10:00

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J Leukoc Biol. 2025 Mar 14:qiaf029. doi: 10.1093/jleuko/qiaf029. Online ahead of print. ABSTRACT Differential diagnosis of immune-related adverse events (irAEs) or bacterial infections is sometimes very difficulty in cancer patients undergoing treatment with PD-(L)1 inhibitors. This study aimed to assess the effectiveness of the neutrophil-to-lymphocyte ratio (NLR) in distinguishing between irAEs and bacterial infections in … Read more

Monoallelic expression in human immune cells: linking genotype to phenotype. Lennart Hammarström

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Trends Immunol. 2025 Mar 12:S1471-4906(25)00032-8. doi: 10.1016/j.it.2025.02.005. Online ahead of print. ABSTRACT Patients with an inborn error of immunity (IEI) often show a complete penetrance of their disease-causing mutation, whereas other forms of IEI show a family pattern where many family members carrying the same mutation remain unaffected. The underlying mechanism, differential allele-specific expression, was … Read more

Efficacy, Safety, Tolerability, and Serum IgG Trough Levels of Hyaluronidase-Facilitated Subcutaneous Immunoglobulin 10% in US Pediatric Patients with Primary Immunodeficiency Diseases

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J Clin Immunol. 2025 Mar 14;45(1):81. doi: 10.1007/s10875-025-01862-6. ABSTRACT PURPOSE: To investigate the efficacy, safety, tolerability, and serum IgG trough levels of hyaluronidase-facilitated subcutaneous immunoglobulin (fSCIG) 10% in US pediatric patients with primary immunodeficiency diseases (PIDDs). METHODS: This phase 3, open-label, prospective study (NCT03277313) was conducted at 17 US centers. Eligible patients aged 2 to … Read more

Monogenic Common Variable Immunodeficiency (Mo‐CVID) Score for Optimizing the Genetic Diagnosis in Pediatric CVID Cohort. [[{“value”:”Federica Barbati, Lorenzo Lodi, Silvia Boscia, Martina Cortimiglia, Elisa Calistri, Francesca Quaranta, Laura Maggi, Alessio Mazzoni, Boaz Palterer, Francesco Annunziato, Chiara Azzari, Silvia Ricci”}]]

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A mutation was identified in 47% of the CVID-enrolled patients and, in the majority, it was not related to CVID according to the IUIS classification, leading to a diagnostic metamorphosis of this pathological entity. The Mo-CVID Score could help clinicians prioritize genetic analysis in pediatric CVID patients. The image was created with BioRender.com. ABSTRACT Common … Read more

The transcription factor RORα is required for the development of type 1 innate lymphoid cells in adult bone marrow

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J Immunol. 2025 Mar 13:vkaf001. doi: 10.1093/jimmun/vkaf001. Online ahead of print. ABSTRACT Type 1 innate lymphoid cells (ILC1s) respond to infections and tumors by producing IFN-γ. Although RAR-related orphan receptor α (RORα) is required for ILC2s and some ILC3s, its role in ILC1 development remains controversial. To investigate the role of RORα in ILC1s, we … Read more

Age and Latent Cytomegalovirus Infection Do Not Affect the Magnitude of De Novo SARS‐CoV‐2‐Specific CD8+ T Cell Responses. [[{“value”:”Jet van den Dijssel, Veronique A. L. Konijn, Mariël C Duurland, Rivka de Jongh, Lianne Koets, Barbera Veldhuisen, Hilde Raaphorst, Annelies W. Turksma, Julian J. Freen‐van Heeren, Maurice Steenhuis, Theo Rispens, C Ellen van der Schoot, S. Marieke van Ham, Rene A. W. van Lier, Klaas P. J. M. van Gisbergen, Anja ten Brinke, Carolien E. van de Sandt”}]]

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Immunosenescence and cytomegalovirus infection are suggested to impair protective immunity against novel pathogens. Despite reduced total CD8+ Tnaïve cells in older CMV– and CMV+ individuals, our study found a broad and robust memory SARS-CoV-2-specific CD8+ T cell response in both younger and older convalescent COVID-19 donors regardless of CMV status. ABSTRACT Immunosenescence, age-related immune dysregulation, … Read more

A Critical Oversight in Immunology Research: The Prevalence of Complement Deficiencies in Mouse Models. África González‐Fernández

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Several mouse strains have a genetic deficiency in the fifth component of complement (C5). This defect affects research outcomes in areas such as allergies, autoimmunity, cancer, infectious diseases, and inflammation. ABSTRACT The complement system is a crucial component of the innate immune response, playing a vital role in defending the body against pathogens and maintaining … Read more

Vaginal Prevotella timonensis Bacteria Enhance HIV‐1 Uptake and Differentially Affect Transmission by Distinct Primary Dendritic Cell Subsets. [[{“value”:”Marleen Y. van Smoorenburg, Ester B. M. Remmerswaal, Celia Segui‐Perez, John L. van Hamme, Karin Strijbis, Teunis B. H. Geijtenbeek”}]]

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The bacterium Prevotella timonensis found in vaginal dysbiosis enhances the uptake of HIV-1 by primary dendritic cells. Virus is internalised into tetraspanin-rich compartments, which leads to efficient HIV-1 transmission to target cells. These results provide insight into how microbiota directly affect HIV-1 uptake thereby altering HIV-1 susceptibility. Created in BioRender. Geijtenbeek, T. (2025) https://BioRender.com/i89c292. ABSTRACT … Read more

Maximizing Insights, Minimizing Animal Testing: A Framework for Validating Multiparametric Single‐Cell Cytokine Analysis Panels. [[{“value”:”Johann Aleith, Wendy Bergmann‐Ewert, Brigitte Müller‐Hilke”}]]

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Multicolor spectral flow cytometry panels for cytokine expression analysis were optimized and validated without animal testing. Stimulated co-cultures of helper T cells, splenocytes, and fibroblast-like synoviocytes provided a complex cellular environment suitable for validating intracellular cytokine staining. This approach offers a more ethical alternative to commonly used animal disease models. ABSTRACT Intracellular cytokine labeling combined … Read more

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